{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:55:32Z","timestamp":1757570132377},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[1982,10,1]],"date-time":"1982-10-01T00:00:00Z","timestamp":402278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1982,10,1]]},"abstract":"<jats:p> Single or repeated subcutaneous administrations of naloxone in doses of up to 4\u2002mg\u2219kg<jats:sup>\u22121<\/jats:sup> did not alter the time for onset or the duration of ethanol- or pentobarbital-induced narcosis in rats. An increase in the naloxone dosage to 50\u2002mg\u2219kg<jats:sup>\u22121<\/jats:sup> s.c. resulted in a small reduction of ethanol-induced sleep duration. Repeated i.p. or i.v. administrations of much higher doses of naloxone (300\u2013400\u2002mg\u2219kg<jats:sup>\u22121<\/jats:sup> and 120\u2013180\u2002mg\u2219kg<jats:sup>\u22121<\/jats:sup>, respectively) did produce significant reductions in ethanol-induced narcosis. However, similar naloxone doses, when administered alone, i.v., had marked convulsant effect. It appears that naloxone, in low doses, is not an effective antidote for narcosis caused by ethanol or pentobarbital at the ethanol and pentobarbital doses tested, whereas the antagonism of ethanol-induced sleep by high doses of naloxone may be due to the analeptic action of this drug. <\/jats:p>","DOI":"10.1139\/y82-194","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T16:49:12Z","timestamp":1303577352000},"page":"1315-1318","source":"Crossref","is-referenced-by-count":21,"title":["Effect of naloxone on ethanol- and pentobarbital-induced narcosis"],"prefix":"10.1139","volume":"60","author":[{"given":"J. M.","family":"Khanna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kalant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y82-194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T11:23:33Z","timestamp":1578223413000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y82-194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1982,10,1]]}},"alternative-id":["10.1139\/y82-194"],"URL":"https:\/\/doi.org\/10.1139\/y82-194","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,10,1]]}}}