{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:27:15Z","timestamp":1785709635403,"version":"3.56.0"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[1983,4,1]],"date-time":"1983-04-01T00:00:00Z","timestamp":418003200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1983,4,1]]},"abstract":"<jats:p> Acute, oral administration of 7.0\u2002mg\/kg calcium carbimide (calcium cyanamide) to rats, 2\u2002h before sacrifice, produced complete inhibition of hepatic, low-K<jats:sub>m<\/jats:sub> (&lt;\u20021\u2002\u03bcM acetaldehyde) mitochondrial and cytosolic aldehyde dehydrogenase enzymes and significantly inhibited high-K<jats:sub>m<\/jats:sub> (~ 1\u2002mM acetaldehyde) mitochondrial, cytosolic, and microsomal aldehyde dehydrogenase isozymes. Calcium carbimide had no effect on several other hepatic enzyme activities including mitochondrial glutamate dehydrogenase and monoamine oxidase, cytosolic alcohol dehydrogenase, microsomal NADPH-cytochrome c reductase, benzo[a]pyrene hydroxylase and aminopyrine N-demethylase activities, and microsomal cytochrome P-450 content. It is concluded that calcium carbimide is a more specific inhibitor of hepatic aldehyde dehydrogenase enzymes than disulfiram. <\/jats:p>","DOI":"10.1139\/y83-065","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:52:38Z","timestamp":1303635158000},"page":"431-435","source":"Crossref","is-referenced-by-count":18,"title":["Specificity of hepatic aldehyde dehydrogenase inhibition by calcium carbimide (calcium cyanamide) in the rat"],"prefix":"10.1139","volume":"61","author":[{"given":"C. W.","family":"Loomis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y83-065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:24:15Z","timestamp":1578241455000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y83-065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1983,4,1]]}},"alternative-id":["10.1139\/y83-065"],"URL":"https:\/\/doi.org\/10.1139\/y83-065","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,4,1]]}}}