{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:24:04Z","timestamp":1756995844245},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[1983,6,1]],"date-time":"1983-06-01T00:00:00Z","timestamp":423273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1983,6,1]]},"abstract":"<jats:p> An assay has been developed for the measurement of salsolinol in brain tissue that involves tissue homogenization in dilute hydrochloric acid, purification of the supernatant by cation-exchange chromatography, derivatization of the eluate with heptafluorobutyric anhydride, and analysis by gas\u2013liquid chromatography with electron capture detection using p-tyramine as the internal standard. The lower limit of quantitative sensitivity, using aqueous standards, is 2.5\u2002ng salsolinol per brain sample. This assay was used to study salsolinol formation in rat brain during the calcium carbimide \u2013 ethanoi interaction. Rats were administered ethanol (1.0\u2002g\/kg) by oral intubation 3\u2002h after intraperitoneal administration of calcium carbimide (7.0\u2002mg\/kg). Saisolinol was measured in the striatum over a 270-min period after ethanol administration. Salsolinol concentration appeared to be maximal (275\u2002ng\/g) at 90\u2002min and then declined with an apparent elimination half-life of 39.8\u2002min. <\/jats:p>","DOI":"10.1139\/y83-097","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T16:50:30Z","timestamp":1303577430000},"page":"632-640","source":"Crossref","is-referenced-by-count":14,"title":["Gas\u2013liquid chromatographic determination of saisolinol in the striatum of rat brain during the calcium carbimide \u2013 ethanol interaction"],"prefix":"10.1139","volume":"61","author":[{"given":"J. F.","family":"Brien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. W.","family":"Loomis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Page","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y83-097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T11:23:42Z","timestamp":1578223422000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y83-097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1983,6,1]]}},"alternative-id":["10.1139\/y83-097"],"URL":"https:\/\/doi.org\/10.1139\/y83-097","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,6,1]]}}}