{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T16:07:59Z","timestamp":1649002079916},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"7","license":[{"start":{"date-parts":[[1984,7,1]],"date-time":"1984-07-01T00:00:00Z","timestamp":457488000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1984,7,1]]},"abstract":"<jats:p> It has been known for a century that extracellular Ca<jats:sup>2+<\/jats:sup> ions are needed for triggering contraction in the heart. However, the two possible mechanisms of Ca<jats:sup>2+<\/jats:sup> entry into the cardiac cells have only been discovered and investigated recently: these are the voltage-gated Ca<jats:sup>2+<\/jats:sup> channels and the Na<jats:sup>+<\/jats:sup>\u2013Ca<jats:sup>2+<\/jats:sup> exchange. This paper reviews the field of the control of cardiac contractility by the sarcolemma and describes various techniques used to study the Ca<jats:sup>2+<\/jats:sup> transport and the corresponding two components of contraction: phasic and tonic tension. The most controversial issue of the past 5 years, attracting the attention of many investigators, is whether or not the Na<jats:sup>+<\/jats:sup>\u2013Ca<jats:sup>2+<\/jats:sup> exchange in the heart is electrogenic and voltage-dependent and thus contributes to the beat-to-beat regulation of free intracellular [Ca<jats:sup>2+<\/jats:sup>]. This paper concentrates on this controversy and gives an up-to-date view of the major steps in the development of our present concept of this transport and of some of the recent experimental approaches. The contribution of an electrogenic, voltage-dependent Na<jats:sup>+<\/jats:sup>\u2013Ca<jats:sup>2+<\/jats:sup> exchange to the regulation of contraction, as well as to cardiac electrical activity, is discussed, and the alterations of both of these cardiac functions due to Na<jats:sup>+<\/jats:sup> accumulation intracellularly (owing to various interventions) are described. <\/jats:p>","DOI":"10.1139\/y84-147","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:53:09Z","timestamp":1303635189000},"page":"874-883","source":"Crossref","is-referenced-by-count":8,"title":["Transmembrane calcium transport and the activation of cardiac contraction"],"prefix":"10.1139","volume":"62","author":[{"given":"Magda","family":"Horackova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y84-147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:22:31Z","timestamp":1578241351000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y84-147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1984,7,1]]}},"alternative-id":["10.1139\/y84-147"],"URL":"https:\/\/doi.org\/10.1139\/y84-147","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,7,1]]}}}