{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:41:07Z","timestamp":1757706067430},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[1984,9,1]],"date-time":"1984-09-01T00:00:00Z","timestamp":462844800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1984,9,1]]},"abstract":"<jats:p> The effects of pretreatment with prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) on salicylate-induced gastric damage in the rat were studied with a gastric chamber model. Transmural potential difference (PD) and net potassium ion (K<jats:sup>+<\/jats:sup>) efflux were monitored as indices of gastric mucosal barrier integrity. Topical application of 20\u2002mM salicylate for 10\u2002min produced an abrupt drop in PD, an increase in net K<jats:sup>+<\/jats:sup> flux, and the formation of hemorrhagic erosions covering approximately 24% of the glandular mucosa. Prior topical application of PGE<jats:sub>2<\/jats:sub> at doses of 25, 75, and 300\u2002\u03bcg\/kg significantly reduced the extent of hemorrhagic erosions. However, PG pretreatment did not produce a reduction in the effects of topical salicylate on either PD or net K<jats:sup>+<\/jats:sup> efflux. Rather, the drop in PD was initially accelerated and the net K<jats:sup>+<\/jats:sup> efflux was increased by PGE<jats:sub>2<\/jats:sub> pretreatment. Subsequently, in PGE<jats:sub>2<\/jats:sub>-pretreated mucosae, both parameters showed more rapid recovery toward control values. These results suggest that the mechanism of \"cytoprotection\" by PGE<jats:sub>2<\/jats:sub> against salicylate-induced gastric damage is not a consequence of preservation of the gastric mucosal barrier. <\/jats:p>","DOI":"10.1139\/y84-178","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T04:53:13Z","timestamp":1303620793000},"page":"1065-1069","source":"Crossref","is-referenced-by-count":13,"title":["Effects of prostaglandin E<sub>2<\/sub> on salicylate-induced damage to the rat gastric mucosa: cytoprotection is not associated with preservation of the gastric mucosal barrier"],"prefix":"10.1139","volume":"62","author":[{"given":"Gerald P.","family":"Morris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia L.","family":"Harding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y84-178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T11:22:51Z","timestamp":1578223371000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y84-178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1984,9,1]]}},"alternative-id":["10.1139\/y84-178"],"URL":"https:\/\/doi.org\/10.1139\/y84-178","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,9,1]]}}}