{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T15:33:01Z","timestamp":1759073581667},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[1986,6,1]],"date-time":"1986-06-01T00:00:00Z","timestamp":517968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1986,6,1]]},"abstract":"<jats:p> N-(2-Cyanoethyl)amphetamine (fenproporex, CE-AM) is a clinically used anorexiant claimed to be devoid of the stimulant properties associated with amphetamine (AM). This claim was inconsistent with preliminary studies conducted in our laboratories which indicated that CE-AM is metabolically dealkylated to AM to a considerable extent in the rat. Concentration\u2013time profiles of CE-AM and its metabolites AM and 4-hydroxyamphetamine (4-OH-AM) in the rat brain were constructed after administration of CE-AM. Analyses of CE-AM, AM, and 4-OH-AM were performed by gas chromatography with electron-capture detection using pentafluorobenzoyl chloride (under aqueous conditions) as the derivatizing reagent. The half-life (t<jats:sub>1\/2<\/jats:sub>) and the maximum concentration (C<jats:sub>max<\/jats:sub>) of AM after administration of CE-AM were calculated to be 2.04 and 0.56 times the respective t<jats:sub>1\/2<\/jats:sub> and C<jats:sub>max<\/jats:sub> obtained after an equimolar dose of AM. Significant differences in the profiles of 4-OH-AM were also observed. The C<jats:sub>max<\/jats:sub> of 4-OH-AM in rat brain after administration of CE-AM was nearly 4 times higher and the t<jats:sub>max<\/jats:sub> (time at which concentration is maximum) 4 times lower than the respective C<jats:sub>max<\/jats:sub> and t<jats:sub>max<\/jats:sub> values of 4-OH-AM observed after an equimolar dose of AM. <\/jats:p>","DOI":"10.1139\/y86-122","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T04:54:16Z","timestamp":1303620856000},"page":"724-728","source":"Crossref","is-referenced-by-count":28,"title":["Metabolism and disposition of <i>N<\/i>-(2-cyanoethyl)amphetamine (fenproporex) and amphetamine: study in the rat brain"],"prefix":"10.1139","volume":"64","author":[{"given":"R. T.","family":"Coutts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Nazarali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. B.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. M.","family":"Pasutto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y86-122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T10:19:23Z","timestamp":1578219563000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y86-122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1986,6,1]]}},"alternative-id":["10.1139\/y86-122"],"URL":"https:\/\/doi.org\/10.1139\/y86-122","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,6,1]]}}}