{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T23:27:46Z","timestamp":1748042866793},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[1987,3,1]],"date-time":"1987-03-01T00:00:00Z","timestamp":541555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1987,3,1]]},"abstract":"<jats:p> Barbiturate actions on excitatory synaptic responses in CA 1 and dentate regions of hippocampal slices were studied to determine whether different effects occur on anatomically distinct synaptic pathways. Pentobarbital facilitated transmission between stratum radiatum inputs and CA 1 neurons at low concentrations (0.02\u20130.08\u2002mM) and produced postsynaptic depression at higher concentrations. Only depression was observed for stratum oriens inputs to CA 1 and perforant path inputs to dentate granulae neurons. The (+) isomer of pentobarbital was approximately four times more potent than the (\u2212) isomer of racemic mixture. Phenobarbital (0.04\u20130.12\u2002mM) produced only depression of synaptic responses in CA 1 and dentate pathways. Comparison of effect on field excitatory postsynaptic potentials and population spike responses indicated that the barbiturates act at selective and pathway-specific sites. The results provide further evidence for specific cellular and membrane recognition sites for barbiturate action. <\/jats:p>","DOI":"10.1139\/y87-065","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T04:54:36Z","timestamp":1303620876000},"page":"385-394","source":"Crossref","is-referenced-by-count":15,"title":["Barbiturate effects on hippocampal excitatory synaptic responses are selective and pathway specific"],"prefix":"10.1139","volume":"65","author":[{"given":"M. Bruce","family":"MacIver","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheldon H.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y87-065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T10:17:15Z","timestamp":1578219435000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y87-065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,3,1]]}},"alternative-id":["10.1139\/y87-065"],"URL":"https:\/\/doi.org\/10.1139\/y87-065","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,3,1]]}}}