{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:16:38Z","timestamp":1771647398984,"version":"3.50.1"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[1987,9,1]],"date-time":"1987-09-01T00:00:00Z","timestamp":557452800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1987,9,1]]},"abstract":"<jats:p> To determine the contribution of the juxtamedullary loop of Henle to magnesium reabsorption during magnesium deficiency, we performed two-phase micropuncture studies of end-descending limbs in a group of magnesium-deficient rats (n\u2002=\u20027) and in a pair-fed control group (n\u2002=\u20028) given MgCl<jats:sub>2<\/jats:sub> in their drinking water. In the magnesium-deficient rats, daily excretion of magnesium fell to very low values (1.2\u2002\u00b1\u20020.2 vs. 52\u2002\u00b1\u200212\u2002\u03bcM\u2219day<jats:sup>\u22121<\/jats:sup>\u2219100\u2002g body weight<jats:sup>\u22121<\/jats:sup>, p\u2002&lt;\u20020.05). Plasma magnesium concentration and fractional magnesium excretion during the control phase were nearly 52 and 27%, respectively, of the values observed in pair-fed controls. Fractional magnesium delivery to the end-descending limb did not differ significantly between the two groups. During the acute magnesium repletion phase, fractional magnesium excretion and fractional magnesium delivery to the end-descending limb increased by a similar value in the two groups of rats, despite a lower filtered load of magnesium in the magnesium-deficient group. Absolute magnesium reabsorption upstream to the end-descending limb was lower in the magnesium-deficient rats but was otherwise tightly coupled to the filtered load of magnesium (Y\u2002=\u20020.91\u2002+\u20020.37 x, r\u2002=\u20020.82, p\u2002&lt;\u20020.05). Similar observations were made with regards to whole kidney magnesium reabsoiption. Our results suggest that, in young magnesium-deficient rats, magnesium reabsorption is tightly coupled to the filtered load of magnesium both in segments upstream to the juxtamedullary end-descending limb and in the whole kidney, and that a reabsorptive defect for magnesium is not evident in this setting. <\/jats:p>","DOI":"10.1139\/y87-298","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:55:12Z","timestamp":1303635312000},"page":"1918-1922","source":"Crossref","is-referenced-by-count":5,"title":["Magnesium reabsorption in the juxtamedullary loop of Henle: effect of magnesium deprivation"],"prefix":"10.1139","volume":"65","author":[{"given":"Denis R.","family":"Roy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y87-298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T15:17:11Z","timestamp":1578237431000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y87-298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1987,9,1]]}},"alternative-id":["10.1139\/y87-298"],"URL":"https:\/\/doi.org\/10.1139\/y87-298","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,9,1]]}}}