{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:02:41Z","timestamp":1782802961805,"version":"3.54.5"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[1987,10,1]],"date-time":"1987-10-01T00:00:00Z","timestamp":560044800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1987,10,1]]},"abstract":"<jats:p> The effects of estrogen and progesterone domination, achieved by administering estrogen (E) and estrogen plus progesterone (E+P), on rat uterine reactivity to Ca<jats:sup>2+<\/jats:sup> and to Ca<jats:sup>2+<\/jats:sup> channel ligands (antagonist and activator) were compared. The inhibitory activities of nifedipine, diltiazem, and D 600 against K<jats:sup>+<\/jats:sup> depolarization-induced responses were not significantly different between E- and E+P-dominated states in longitudinal or circular muscle preparations. Tonic responses were significantly more sensitive than phasic responses, but the rank orders of activity for a series of 14 antagonists were identical, suggesting the existence of a common structure\u2013activity relationship which paralleled that seen previously in other smooth muscles. E+P-dominated uteri were slightly more sensitive to Ca<jats:sup>2+<\/jats:sup> responses in K<jats:sup>+<\/jats:sup> depolarizing media, but pA<jats:sub>2<\/jats:sub> values for nifedipine, diltiazem, and D 600 inhibition were not significantly different in tissues from animals in either hormone-dominated state. Binding of [<jats:sup>3<\/jats:sup>H]nitrendipine did not differ between hormonal states. Responses to Bay K 8644 were larger in E+P-dominated uteri but the binding density was twofold greater in the E-dominated uterus. This study suggests that pathways of Ca<jats:sup>2+<\/jats:sup> mobilization through potential-dependent Ca<jats:sup>2+<\/jats:sup> channels in rat uterus are not significantly altered between E- and E+P-dominated environments. <\/jats:p>","DOI":"10.1139\/y87-327","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T04:55:33Z","timestamp":1303620933000},"page":"2085-2092","source":"Crossref","is-referenced-by-count":10,"title":["Ca<sup>2+<\/sup> channel ligand activities in uterine smooth muscle: influence of hormonal status"],"prefix":"10.1139","volume":"65","author":[{"given":"A. L.","family":"Ruzycky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Crankshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Triggle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y87-327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T10:17:20Z","timestamp":1578219440000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y87-327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1987,10,1]]}},"alternative-id":["10.1139\/y87-327"],"URL":"https:\/\/doi.org\/10.1139\/y87-327","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,10,1]]}}}