{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T11:15:39Z","timestamp":1679656539744},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[1988,10,1]],"date-time":"1988-10-01T00:00:00Z","timestamp":591667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1988,10,1]]},"abstract":"<jats:p> In short-term experiments, male Wistar rats were made diabetic for 10 days with a single injection of streptozotocin (65\u2002mg\/kg body weight). One group of diabetic rats was treated with insulin for 3 days prior to sacrifice. In long-term experiments, vitamin D replete or vitamin D depleted rats were made diabetic for 6 weeks. Criteria for diabetes were loss of weight, glycosuria (Tes-Tape), and hyperglycemia. In long-term diabetic rats the activity of renal mitochondrial 25-hydroxyvitamin D<jats:sub>3<\/jats:sub> (25-(OH)D<jats:sub>3<\/jats:sub>) 1\u03b1-hydroxylase was significantly decreased and that of 25-(OH)D<jats:sub>3<\/jats:sub> 24-hydroxylase increased. However, the parathyroid hormone (PTH) sensitive renal adenylate cyclase activity of diabetic rats was not different from that of the nondiabetic rats in either the vitamin D replete group or the vitamin D depleted group. On the other hand, the PTH-sensitive renal adenylate cyclase activity was significantly higher in short-term diabetic rats than in control and insulin-treated rats. These differences were observed at doses of 10<jats:sup>\u22128<\/jats:sup> to 10<jats:sup>\u22125<\/jats:sup>\u2002M of PTH. This study has demonstrated for the first time that there are differences in the PTH-sensitive adenylate cyclase response between long-term and short-term diabetic rats. The hypersensitivity to PTH of the renal adenylate cyclase observed in short-term diabetic rats probably represents a response to insulin deficiency during the early development of diabetes mellitus in the rats. <\/jats:p>","DOI":"10.1139\/y88-215","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T20:54:16Z","timestamp":1303592056000},"page":"1313-1318","source":"Crossref","is-referenced-by-count":3,"title":["Effect of long-term and short-term diabetes on the parathyroid hormone sensitive rat renal adenylate cyclase: correlation with vitamin D metabolism"],"prefix":"10.1139","volume":"66","author":[{"given":"L. G.","family":"Rao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. S.","family":"Kung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y88-215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T15:16:45Z","timestamp":1578237405000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y88-215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1988,10,1]]}},"alternative-id":["10.1139\/y88-215"],"URL":"https:\/\/doi.org\/10.1139\/y88-215","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10,1]]}}}