{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T14:42:31Z","timestamp":1648824151803},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[1989,6,1]],"date-time":"1989-06-01T00:00:00Z","timestamp":612662400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1989,6,1]]},"abstract":"<jats:p> Acid\u2013base status is considered the major factor controlling renal [Formula: see text] production from glutamine, with maximal values found in chronic acidosis. However, metabolic inhibitors have been shown to increase [Formula: see text] production without acid\u2013base change; the mechanism for this increase is unclear. Fluorocitrate was administered to dogs with chronic metabolic alkalosis. Following fluorocitrate total renal [Formula: see text] production rose from 32\u2002\u00b1\u20025 to 104\u2002\u00b1\u200215\u2002\u03bcmol\/(min\u2219100\u2002mL glomerular filtration rate (GFR)) (p\u2002&lt;\u20020.01) and glutamine extraction rose from 26\u2002\u00b1\u20028 to 65\u2002\u00b1\u20028\u2002\u03bcmol\/(min\u2219100\u2002mL GFR) (p\u2002&lt;\u20020.01). These values approximate maximal values found in chronic acidosis. Lactate utilization fell from 165\u2002\u00b1\u200219 to 99\u2002\u00b1\u20027\u2002\u03bcmol\/(min\u2219100\u2002mL GFR) following fluorocitrate (p\u2002&lt;\u20020.01). Citrate extraction fell to zero and alanine production rose from 27\u2002\u00b1\u20024 to 46\u2002\u00b1\u20027\u2002\u03bcmol\/(min\u2219100\u2002mL GFR) (p\u2002&lt;\u20020.01). Oxygen consumption remained unchanged following fluorocitrate, 584\u2002\u00b1\u200229 vs. 549\u2002\u00b1\u200229\u2002\u03bcmol\/(min\u2219100\u2002mL GFR). These results demonstrate that in the presence of metabolic inhibition in the kidney, ATP production remains constant. This is achieved by increased utilization of one substrate, glutamine, when the ATP production from other substrates is reduced. Thus the necessity to maintain constant ATP production appears to modulate renal [Formula: see text] production.Key words: ammonium production, metabolic inhibitors, oxygen uptake. <\/jats:p>","DOI":"10.1139\/y89-102","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T04:56:33Z","timestamp":1303620993000},"page":"641-644","source":"Crossref","is-referenced-by-count":1,"title":["The effects of fluorocitrate on renal glutamine, lactate, alanine, and oxygen metabolism in the dog"],"prefix":"10.1139","volume":"67","author":[{"given":"A.","family":"Fine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y89-102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T10:15:11Z","timestamp":1578219311000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y89-102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,6,1]]}},"alternative-id":["10.1139\/y89-102"],"URL":"https:\/\/doi.org\/10.1139\/y89-102","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,6,1]]}}}