{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:03:27Z","timestamp":1768320207555,"version":"3.49.0"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[1989,12,1]],"date-time":"1989-12-01T00:00:00Z","timestamp":628473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1989,12,1]]},"abstract":"<jats:p> Removal of the salivary glands (SALX) in rats has been shown to increase the susceptibility of gastric mucosa to ulcerogens. In the present study, we have investigated the role of specific salivary glands in this response. In addition, we have examined whether a functional link exists between the salivary glands, epidermal growth factor (EGF), and prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) by determining whether SALX decreases the responsiveness of the mucosa to the protective actions of either of both of these agents. Removal of the parotid salivary glands did not significantly increase ulceration in response to intragastric administration of 100%\u2002w\/v ethanol. Animals were examined 60\u2002min after ethanol administration. Removal of the submandibular\u2013sublingual gland complexes was associated with a significant increase in the area of mucosal damage and a decrease in gastric pit depth in ethanol-treated animals when compared with sham-operated control rats. Furthermore, in both SALX and control animals, exogenous PGE<jats:sub>2<\/jats:sub> and EGF resulted in a dose-dependent reduction in both groups of animals, although the protective effects of PGE<jats:sub>2<\/jats:sub> and EGF were attenuated in SALX rats. PGE<jats:sub>2<\/jats:sub> and EGF administered in combination resulted in the same degree of protection in both SALX and control rats. Sialoadenectomy resulted in a reduction in mucosal PGE<jats:sub>2<\/jats:sub> synthesis. EGF administration did not consistently increase mucosal PGE<jats:sub>2<\/jats:sub> synthesis. Conversely, sialoadenectomy did not reduce mucosal levels of EGF nor did exogenous PGE<jats:sub>2<\/jats:sub> consistently increase salivary or mucosal content of EGF. If animals were examined 5\u2002min after ethanol instillation, there were no differences in the degree of damage between SALX and control animals whether determined by measuring surface areas of lesions or changes in histology. These data suggest that SALX is associated with a reduction in the responsiveness of rat gastric mucosa to PGE<jats:sub>2<\/jats:sub> and EGF. The data is not totally consistent with reductions in endogenous levels or synthesis of these agents.Key words: salivary glands, mucosal integrity, EGF immunoassay, PGE<jats:sub>2<\/jats:sub> synthesis. <\/jats:p>","DOI":"10.1139\/y89-244","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:56:50Z","timestamp":1303635410000},"page":"1512-1519","source":"Crossref","is-referenced-by-count":6,"title":["The effect of sialoadenectomy on gastric mucosal integrity in the rat: roles of epidermal growth factor and prostaglandin E<sub>2<\/sub>"],"prefix":"10.1139","volume":"67","author":[{"given":"B. L.","family":"Tepperman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Kiernan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. D.","family":"Soper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y89-244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T15:15:33Z","timestamp":1578237333000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y89-244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1989,12,1]]}},"alternative-id":["10.1139\/y89-244"],"URL":"https:\/\/doi.org\/10.1139\/y89-244","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,12,1]]}}}