{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:24:36Z","timestamp":1761488676918},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[1991,3,1]],"date-time":"1991-03-01T00:00:00Z","timestamp":667785600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1991,3,1]]},"abstract":"<jats:p> The effect on blood pressure and heart rate of central administration of dynorphin A(1 \u2013 13) and of \u03b2-, \u03b3-, and \u03b1-endorphin related peptides was studied in urethane-anesthetized rats. Intracerebroventricular (i.c.v., 0.1 \u2013 10\u2002\u03bcg) administration of \u03b2-endorphin resulted in a dose-dependent, naltrexone-reversible hypotension and bradycardia. N-terminally modified fragments of \u03b2-endorphin did not reduce blood pressure and heart rate. On the other hand, a dose of 10\u2002\u03bcg of \u03b2-endorphin(1 \u2013 27), which lacks the four C-terminal amino acid residues of \u03b2-endorphin, induced a fall in blood pressure and had a biphasic effect on heart rate. These responses, however, were resistant to pretreatment with naltrexone. None of the fragments of \u03b2-endorphin smaller than \u03b2-endorphin(1 \u2013 27) affected blood pressure when administered i.c.v. in a dose of 10\u2002\u03bcg. A small transient bradycardia was observed after i.c.v. administration of 10\u2002\u03bcg of \u03b2-endorphin(1 \u2013 26), \u03b1-, and \u03b3-endorphin. The naltrexone-reversible bradycardic response of \u03b1- and \u03b3-endorphin was not present in des-tyrosine- and des-enkephalin-\u03b1- and \u03b3-endorphin and also not in \u03b1-endorphin(10 \u2013 16) and \u03b3-endorphin(10 \u2013 17). Upon i.c.v. administration (0.1 \u2013 50\u2002\u03bcg) a dose-dependent, naltrexone-reversible decrease in blood pressure and heart rate was induced by dynorphin A(1 \u2013 13). The present data indicate a hypotensive influence of \u03b2-endorphin, \u03b2-endorphin(1 \u2013 27), and dynorphin A(1 \u2013 13), whereas other fragments of \u03b2-endorphin had little or no effect on the cardiovascular parameters investigated.Key words: \u03b2-endorphin fragments, blood pressure, heart rate, dynorphin A(1 \u2013 13), anesthetized rats. <\/jats:p>","DOI":"10.1139\/y91-050","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T04:58:18Z","timestamp":1303621098000},"page":"327-333","source":"Crossref","is-referenced-by-count":20,"title":["Effects of dynorphin A(1 \u2013 13) and of fragments of \u03b2-endorphin on blood pressure and heart rate of anesthetized rats"],"prefix":"10.1139","volume":"69","author":[{"given":"Paul L. M. van","family":"Giersbergen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk de","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wybren de","family":"Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y91-050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T10:23:17Z","timestamp":1578219797000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y91-050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,3,1]]}},"alternative-id":["10.1139\/y91-050"],"URL":"https:\/\/doi.org\/10.1139\/y91-050","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,3,1]]}}}