{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:27:24Z","timestamp":1758637644024},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"7","license":[{"start":{"date-parts":[[1991,7,1]],"date-time":"1991-07-01T00:00:00Z","timestamp":678326400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1991,7,1]]},"abstract":"<jats:p> The stereoselectivities of \u03b2-adrenergic partial agonists for the high affinity binding site of \u03b2-adrenoceptors in the rabbit ciliary body and the guinea-pig taenia caeci were studied. The pA<jats:sub>2<\/jats:sub> values of the S-(\u2212)-isomers of befunolol and carteolol against S-(\u2212)-isoprenaline, which were calculated from the shift of each concentration\u2013response curve in increasing cyclic AMP levels, were significantly larger than those of the R-(+)-isomers in the guinea-pig taenia caeci, while the pA<jats:sub>2<\/jats:sub> values of the S-(\u2212)-isomers were not significantly larger than those of the R-(+)-isomers in the rabbit ciliary body. The pK<jats:sub>i<\/jats:sub> values determined from the binding experiments were in good agreement with the pA<jats:sub>2<\/jats:sub> values from the increases in cyclic AMP levels. These results suggest that the high affinity binding site of \u03b2-adrenoceptors in the guinea-pig taenia caeci may be able to discriminate stereoselectively between the R-(+)- and S-(\u2212)-isomers, while in the rabbit ciliary body there is no stereoselectivity between the two enantiomers.Key words: stereoselectivity, \u03b2-adrenoceptor, partial agonist, rabbit ciliary body, guinea-pig taenia caeci. <\/jats:p>","DOI":"10.1139\/y91-144","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:58:25Z","timestamp":1303635505000},"page":"951-957","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of interactions of <i>R<\/i>-(+)- and <i>S<\/i>-(\u2212)-isomers of \u03b2-adrenergic partial agonists, befunolol and carteolol, with high affinity site of \u03b2-adrenoceptors in isolated rabbit ciliary body and guinea-pig taenia caeci"],"prefix":"10.1139","volume":"69","author":[{"given":"Katsuo","family":"Koike","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Hagiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issei","family":"Takayanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y91-144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T15:23:33Z","timestamp":1578237813000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y91-144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1991,7,1]]}},"alternative-id":["10.1139\/y91-144"],"URL":"https:\/\/doi.org\/10.1139\/y91-144","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7,1]]}}}