{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T10:31:44Z","timestamp":1693650704215},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[1992,4,1]],"date-time":"1992-04-01T00:00:00Z","timestamp":702086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1992,4,1]]},"abstract":"<jats:p> In order to compare the importance of Na<jats:sup>+<\/jats:sup>\u2013Ca<jats:sup>2+<\/jats:sup> exchange in the regulation of cytosolic Ca<jats:sup>2+<\/jats:sup> concentration [Formula: see text], acini obtained from rat pancreas and submandibular glands as well as cardiac myocytes were loaded with Na<jats:sup>+<\/jats:sup> by inhibition of Na<jats:sup>+<\/jats:sup>\u2013K<jats:sup>+<\/jats:sup> ATPase activity then loaded with rara-2. In the exocrine tissues, incubation in K<jats:sup>+<\/jats:sup>-free buffer or with ouabain had no substantial effect on resting [Formula: see text] or on the changes in [Formula: see text] following exposure to carbachol as compared with acini incubated under control conditions. In contrast, rat cardiac myocytes, treated identically, showed marked changes in [Formula: see text] under resting and stimulated conditions as compared with controls. We conclude that the Na<jats:sup>+<\/jats:sup>\u2013Ca<jats:sup>2+<\/jats:sup> exchange systems of rat pancreatic and submandibular gland acini contribute little to the overall regulation of [Formula: see text] at rest during cholinergic stimulation.Key words: submandibular glands, pancreatic acini, salivary glands, fura-2, cytosolic Ca<jats:sup>2+<\/jats:sup>, Na<jats:sup>+<\/jats:sup>\u2013Ca<jats:sup>2+<\/jats:sup> exchange. <\/jats:p>","DOI":"10.1139\/y92-060","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T04:58:44Z","timestamp":1303621124000},"page":"461-465","source":"Crossref","is-referenced-by-count":2,"title":["Differing significance of Na<sup>+<\/sup>\u2013Ca<sup>2+<\/sup> exchange in the regulation of cytosolic Ca<sup>2+<\/sup> in rat exocrine gland acini and cardiac myocytes"],"prefix":"10.1139","volume":"70","author":[{"given":"Thomas W.","family":"Hurley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Dale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Rovetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y92-060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T10:22:34Z","timestamp":1578219754000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y92-060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,4,1]]}},"alternative-id":["10.1139\/y92-060"],"URL":"https:\/\/doi.org\/10.1139\/y92-060","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4,1]]}}}