{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:18:26Z","timestamp":1754111906689},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[1992,4,1]],"date-time":"1992-04-01T00:00:00Z","timestamp":702086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1992,4,1]]},"abstract":"<jats:p> Inflammatory mediators can both enhance or inhibit canine airway reactivity. PGE<jats:sub>2<\/jats:sub> and PGI<jats:sub>2<\/jats:sub> in general are inhibitory, interfering with release of acetylcholine and with responses to bronchoconstrictors. These prostaglandins may be more effective against agonists that open voltage-dependent Ca<jats:sup>2+<\/jats:sup> channels to induce Ca<jats:sup>2+<\/jats:sup> influx and contraction compared with those agonists that release internal Ca<jats:sup>2+<\/jats:sup>. Other mediators are excitatory: histamine, PGD<jats:sub>2<\/jats:sub>, thromboxane A<jats:sub>2<\/jats:sub> (TxA<jats:sub>2<\/jats:sub>), and leukotrienes (LT) C<jats:sub>4<\/jats:sub>, D<jats:sub>4<\/jats:sub>, and E<jats:sub>4<\/jats:sub>. In canine airway only histamine and TxA<jats:sub>2<\/jats:sub> have effects in the absence of indomethacin, i.e., in the presence of the large amounts of PGE<jats:sub>2<\/jats:sub> and PGI<jats:sub>2<\/jats:sub> produced in vitro LTs are ineffective. Effects of TxA<jats:sub>2<\/jats:sub> and histamine may be potentiated if the synthesis of these inhibitory PGs is inhibited. Whether histamine or TxA<jats:sub>2<\/jats:sub> normally promote synthesis and release of PGE<jats:sub>2<\/jats:sub> and PGI<jats:sub>2<\/jats:sub> in a kind of homeostasis remains to be explored. It is also unclear whether pre- as well as post-junctional TxA<jats:sub>2<\/jats:sub> receptors exist and have different pharmacological sensitivities to antagonists. LTC<jats:sub>4<\/jats:sub> and LTD<jats:sub>4<\/jats:sub> also constrict canine bronchi but only when PGE<jats:sub>2<\/jats:sub> and PGI<jats:sub>2<\/jats:sub> synthesis is blocked and, again, whether this is a result of LT-induced release of inhibitory mediators is unknown. The concept that airway responsiveness can be caused by turning off PGE<jats:sub>2<\/jats:sub> and PGI<jats:sub>2<\/jats:sub> production and turning on TxA<jats:sub>2<\/jats:sub> or LT production (or unmasking their actions) needs further exploration. Our recent data suggest that such a mechanism may explain ozone-induced responsiveness in dogs.Key words: histamine, thromboxane A<jats:sub>2<\/jats:sub>, leukotrienes C<jats:sub>4<\/jats:sub> and D<jats:sub>4<\/jats:sub>, PGE<jats:sub>2<\/jats:sub>, PGI<jats:sub>2<\/jats:sub>. <\/jats:p>","DOI":"10.1139\/y92-080","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:58:44Z","timestamp":1303635524000},"page":"624-634","source":"Crossref","is-referenced-by-count":7,"title":["Effects of inflammatory mediators on canine airway neuromuscular function"],"prefix":"10.1139","volume":"70","author":[{"given":"E. E.","family":"Daniel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. P.","family":"Abela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. J.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"O'Byrne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y92-080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T15:22:46Z","timestamp":1578237766000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y92-080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,4,1]]}},"alternative-id":["10.1139\/y92-080"],"URL":"https:\/\/doi.org\/10.1139\/y92-080","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4,1]]}}}