{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:45:34Z","timestamp":1791085534343,"version":"4.1.0"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"S1","license":[{"start":{"date-parts":[[1992,5,15]],"date-time":"1992-05-15T00:00:00Z","timestamp":705888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1992,5,15]]},"abstract":"<jats:p> The pH<jats:sub>i<\/jats:sub> regulation from intracellular acidosis in the central nervous system appears to be mediated by mechanisms driven by the large inwardly directed Na<jats:sup>+<\/jats:sup> gradient. The involvement of these mechanisms in pH<jats:sub>i<\/jats:sub> regulation of neurones and glial cells has been investigated in the leech central nervous system using ion-selective microelectrodes. For recovery from acidification, there appear to be three separate mechanisms: Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> exchange, Na<jats:sup>+<\/jats:sup>-dependent Cl<jats:sup>\u2212<\/jats:sup>\/HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> exchange, and Na<jats:sup>+<\/jats:sup>\u2013HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> cotransport. All three mechanisms have a profound effect on the maintenance of pH<jats:sub>i<\/jats:sub> homeostasis in glial ceils; whereas in leech neurones, as in other neuronal cells studied previously, the predominant mechanisms are Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> and Na<jats:sup>+<\/jats:sup>-dependent Cl<jats:sup>\u2212<\/jats:sup>\/HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> exchange. In addition to acid extrusion mechanisms we also found evidence for Na<jats:sup>+<\/jats:sup>-independent Cl<jats:sup>\u2212<\/jats:sup>\/HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> exchange. At alkaline pH<jats:sub>i<\/jats:sub> this exchanger may mediate some of the pH<jats:sub>i<\/jats:sub> recovery from intracellular alkalinization.Key words: central nervous system, pH regulation, neurotransmitter. <\/jats:p>","DOI":"10.1139\/y92-273","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T04:59:07Z","timestamp":1303621147000},"page":"S278-S285","source":"Crossref","is-referenced-by-count":14,"title":["The regulation of pH in the central nervous system"],"prefix":"10.1139","volume":"70","author":[{"given":"W.-R.","family":"Schlue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"D\u00f6rner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y92-273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T10:22:19Z","timestamp":1578219739000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y92-273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5,15]]},"references-count":0,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[1992,5,15]]}},"alternative-id":["10.1139\/y92-273"],"URL":"https:\/\/doi.org\/10.1139\/y92-273","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5,15]]}}}