{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:32:40Z","timestamp":1762101160105},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1994,1,1]]},"abstract":"<jats:p> Three Holstein steers (345\u2002\u00b1\u200222\u2002kg) surgically fitted with a pancreatic cannula were used in two 3\u2002\u00d7\u20023 Latin square design experiments to examine the effects of slaframine (SF), a muscarinic agonist, or 4-diphenylacetoxy-N-methylpiperidine methiodide (4DAMP), an M<jats:sub>3<\/jats:sub> muscarinic glandular receptor antagonist, on pancreatic exocrine secretion. Pancreatic exocrine secretion was collected for 8\u2002h postdosing at 30-min intervals beginning 1\u2002h postfeeding. In experiment 1, steers were dosed with 0, 25, or 50\u2002\u03bcg\u2219kg<jats:sup>\u22121<\/jats:sup> body weight (BW) of SF. Secretion of pancreatic juice and the pH of the secreted juice increased linearly (p\u2002&lt;\u20020.05) with SF; however, secretion rate showed a time by treatment interaction (p\u2002&lt;\u20020.05), as treatments converged 7\u2002h postdosing. Trypsin secretion tended (p\u2002&lt;\u20020.10) to show a quadratic response to SF administration, with the 25\u2002\u03bcg SF\u2219kg<jats:sup>\u22121<\/jats:sup> BW dose having the lowest value. In experiment 2, steers received 50\u2002\u03bcg\u2219kg<jats:sup>\u22121<\/jats:sup> BW of SF (positive control), 113\u2002\u03bcg\u2219kg<jats:sup>\u22121<\/jats:sup> BW of 4DAMP (isomolar with SF), or both. SF caused a greater pancreatic fluid secretion (p\u2002&lt;\u20020.10) than 4DAMP, with SF plus 4DAMP intermediate. A time by treatment interaction (p\u2002&lt;\u20020.04) was found, since treatments converged 8\u2002h postdosing. Trypsin secretion was higher (p\u2002&lt;\u20020.05) for SF than the other treatments. Chymotrypsin, \u03b1-amylase, and protein secretion were not affected. SF and 4DAMP alter pancreatic fluid secretion in the steer but have minimal effects on enzyme secretions.Key words: slaframine, 4-diphenylacetoxy-N-methylpiperidine methiodide, bovine, pancreatic exocrine secretion. <\/jats:p>","DOI":"10.1139\/y94-007","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T21:04:23Z","timestamp":1303592663000},"page":"39-44","source":"Crossref","is-referenced-by-count":15,"title":["Effects of slaframine and 4-diphenylacetoxy-<i>N<\/i>-methylpiperidine methiodide (4DAMP) on pancreatic exocrine secretion in the bovine"],"prefix":"10.1139","volume":"72","author":[{"given":"J. A.","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Krehbiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. L.","family":"Harmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"St. Jean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. J.","family":"Croom Jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. M.","family":"Hagler Jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y94-007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T15:21:39Z","timestamp":1578237699000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y94-007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1,1]]}},"alternative-id":["10.1139\/y94-007"],"URL":"https:\/\/doi.org\/10.1139\/y94-007","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1,1]]}}}