{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T05:08:53Z","timestamp":1741237733051,"version":"3.38.0"},"reference-count":9,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1995,3,1]]},"abstract":"<jats:p>Lectins, known to recognize endothelial cell adhesion molecules, have been shown to release endothelium-derived relaxing factor (EDRF) from blood vessels. We investigated the effects of different leukocyte-type cells to determine if these cells, by interacting with the endothelium, could release EDRF from the circumflex branch of the canine coronary artery. The following cells were investigated: human promyelocytic leukemia (HL-60), human monocyte (THP-1), and human Burkitt lymphoma (DAUDI). All of these cells produced a significant endothelium-dependent relaxation of the dog coronary artery in the presence of ibuprofen. The endothelium-dependent relaxations were reversed by hemoglobin (10\u2002\u03bcM), methylene blue (3\u2002\u03bcM), 6-anilino-5,8-quinolinedione (LY 83583, 30\u2002\u03bcM), and N<jats:sup>G<\/jats:sup>-nitro-L-arginine methyl ester (L-NAME, 1\u2002mM). HL-60 cells grown in the presence of 1\u2002mM L-NAME retained their ability to cause endothelium-dependent relaxation of the canine coronary artery, suggesting that the source of the NO was the endothelium and not the HL-60 cells. The cell-induced vascular relaxation could be obtained in the absence of extracellular calcium. It is suggested that HL-60, THP-1, and DAUDI cells interact with a specific receptor on the endothelial cell and as a result of this interaction the endothelial cells are stimulated to release EDRF.Key words: endothelium-derived relaxing factor, nitric oxide, endothelium, HL-60, DAUDI, THP-1, smooth muscle, calcium, contraction, canine coronary artery.<\/jats:p>","DOI":"10.1139\/y95-052","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:59:38Z","timestamp":1303635578000},"page":"404-408","source":"Crossref","is-referenced-by-count":2,"title":["Endothelium derived relaxing factor release from canine coronary artery by leukocytes"],"prefix":"10.1139","volume":"73","author":[{"given":"Joseph F.","family":"Kleha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Devesly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Johns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.pa.24.040184.001135","volume":"24","author":"Furchgott W.F.","year":"1984","journal-title":"Rev. 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