{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T14:19:02Z","timestamp":1698589142736},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[1995,6,1]],"date-time":"1995-06-01T00:00:00Z","timestamp":801964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1995,6,1]]},"abstract":"<jats:p> The effect of ionizing radiation on jejunal blood flow was investigated in rats receiving whole-body exposure to 10\u2002Gy \u03b3-radiation. Irradiation resulted in increased myeloperoxidase activity, indicative of neutrophil infiltration, and prostaglandin E<jats:sub>2<\/jats:sub> synthesis by 2\u2002h post-irradiation, but had no effect on leukotriene B<jats:sub>4<\/jats:sub> synthesis. In ex vivo intestinal chamber studies, exposure to radiation reversed the mucosal\u2013submucosal blood flow changes elicited by intravenous administration of leukotriene C<jats:sub>4<\/jats:sub> (1\u2002\u03bcg\u2219kg<jats:sup>\u22121<\/jats:sup>\u2219min<jats:sup>\u22121<\/jats:sup> for 10\u2002min) or endothelin 1 (1\u2002\u03bcg\u2219kg<jats:sup>\u22121<\/jats:sup>\u2219min<jats:sup>\u22121<\/jats:sup> for 5\u2002min), but not that elicited by topical capsaicin (100 or 640\u2002\u03bcM), as measured by laser Doppler flowmetry. The effect of radiation on vascular responses to leukotriene C<jats:sub>4<\/jats:sub>, but not those to endothelin 1, was reversed by pretreatment of the rats with the cyclooxygenase inhibitor, indomethacin (5\u2002mg\/kg). There was no significant effect of irradiation on mean arterial pressure or on ion or protein effluxes into the chamber bathing solution, nor did irradiation alter transmural potential difference. These studies point to altered responsiveness of the jejunal mucosal\u2013submucosal vasculature shortly after exposure to ionizing radiation. Changes in function could reflect the onset of an acute inflammatory response, and appear to have cyclooxygenase-dependent and -independent components.Key words: intestine, blood flow, inflammation, leukotriene, endothelin. <\/jats:p>","DOI":"10.1139\/y95-090","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T05:02:05Z","timestamp":1303621325000},"page":"699-705","source":"Crossref","is-referenced-by-count":4,"title":["Exposure to ionizing radiation alters vasoreactivity in rat jejunum ex vivo"],"prefix":"10.1139","volume":"73","author":[{"given":"Wallace K.","family":"MacNaughton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Prud'homme-Lalonde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y95-090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T10:34:50Z","timestamp":1578220490000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y95-090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,6,1]]}},"alternative-id":["10.1139\/y95-090"],"URL":"https:\/\/doi.org\/10.1139\/y95-090","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6,1]]}}}