{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T17:53:14Z","timestamp":1699638794576},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[1971,6,1]],"date-time":"1971-06-01T00:00:00Z","timestamp":44582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1971,6,1]]},"abstract":"<jats:p> BS-4231, a new sulfonylurea, stimulates insulin secretion by incubated pieces of rat pancreatic tissue. The minimal effective dose is between 3 and 30\u2002m\u03bcg\/ml. The insulinotropic effect of this agent is transient. It is more marked at intermediate (1.0 and 1.5\u2002mg\/ml) than either at high glucose concentrations (3.0\u2002mg\/ml) or in the absence of glucose. Experimental data obtained with various inhibitors of insulin secretion suggest that (i) epinephrine suppresses the stimulant action of BS-4231, as well as that of glucose; (ii) mannoheptulose modulates the insulinotropic action of BS-4231 indirectly by altering the effect of extracellular glucose; and (iii) diazoxide faiis to exert any effect upon insulin secretion in the presence of BS-4231. On the basis of these results, it is suggested that BS-4231 might accelerate within the beta-cell some step of glucose metabolism, which is rate-limiting when the insulin secretory process is not fully stimulated by extracellular glucose. <\/jats:p>","DOI":"10.1139\/y71-069","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T20:40:39Z","timestamp":1303591239000},"page":"536-544","source":"Crossref","is-referenced-by-count":10,"title":["Insulinotropic Effect and Possible Mode of Action of a New Potent Sulfonylurea (BS-4231)"],"prefix":"10.1139","volume":"49","author":[{"given":"Guy R.","family":"Brisson","sequence":"first","affiliation":[]},{"given":"Willy J.","family":"Malaisse","sequence":"additional","affiliation":[]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y71-069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:17:46Z","timestamp":1578241066000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y71-069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1971,6,1]]}},"alternative-id":["10.1139\/y71-069"],"URL":"https:\/\/doi.org\/10.1139\/y71-069","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,6,1]]}}}