{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T14:57:22Z","timestamp":1699714642705},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[1976,12,1]],"date-time":"1976-12-01T00:00:00Z","timestamp":218246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1976,12,1]]},"abstract":"<jats:p> To determine whether rats could adapt to a chronic exogenous supply of adrenaline by a decrease in the well-known inhibitory effect of adrenaline on insulin secretion, plasma glucose and insulin levels were measured in unanesthetized control and adrenaline-treated rats (300\u2002\u03bcg\/kg twice a day for 28 days) during an adrenaline infusion (0.75\u2002\u03bcg kg<jats:sup>\u22121<\/jats:sup> min<jats:sup>\u22121<\/jats:sup>), after an acute glucose load (0.5\u2002g\/kg), and during the simultaneous administration of both agents. Chronic treatment with adrenaline did not modify the initial glucose levels but it greatly diminished the basal insulin values (21.57\u2002\u00b1\u20022.48\u2002vs. 44.69\u2002\u00b1\u20023.3\u2002\u03bcU\/ml, p\u2002&lt; 0.01). In the control rats, despite the elevated glucose concentrations, a significant drop in plasma insulin levels was observed within the first 15\u2002min of adrenaline infusion, followed by a period of recovery. In the adrenaline-treated group, in which plasma glucose levels were lower than in control animals, plasma insulin levels did not drop as in control rats, but a significant increase was found after 30\u2002min of infusion. During the intravenous glucose tolerance test, the plasma glucose and insulin responses showed similar patterns; however, during the concomitant adrenaline infusion, the treated rats showed a better glucose tolerance than their controls. These results indicate that rats chronically treated with adrenaline adapt to the diabetogenic effect of an infusion of adrenaline by having a lower inhibition of insulin release, although the lower basal insulin levels may indicate a greater sensitivity to endogenous insulin. <\/jats:p>","DOI":"10.1139\/y76-121","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T16:44:35Z","timestamp":1303577075000},"page":"870-875","source":"Crossref","is-referenced-by-count":10,"title":["Effect of adrenaline on insulin secretion in rats treated chronically with adrenaline"],"prefix":"10.1139","volume":"54","author":[{"given":"Suzanne","family":"Rousseau-Migneron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Nadeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"LeBlanc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y76-121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T11:20:25Z","timestamp":1578223225000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y76-121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1976,12,1]]}},"alternative-id":["10.1139\/y76-121"],"URL":"https:\/\/doi.org\/10.1139\/y76-121","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,12,1]]}}}