{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:26:54Z","timestamp":1774542414101,"version":"3.50.1"},"reference-count":53,"publisher":"Canadian Science Publishing","issue":"7","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p> Immunosenescence contribute to increase the blood-brain barrier (BBB) permeability, leading cognitive impairment and neurodegeneration. Thus, we investigated the anti-inflammatory effect of exercise and taurine supplementation on peripheral markers of BBB, inflammation, and cognition of elderly women. Forty-eight elderly women (age, 83.58 \u00b1 6.9 years) participated in the study, and were allocated into combined exercise training (CET: n = 13), taurine supplementation (TAU: n = 12), exercise training associated with taurine (CET+TAU: n = 11), or control (CG: n = 12) groups. Exercise was applied twice a week (multi-modal exercise). Taurine ingestion was 1.5 g., once a day. Participants were evaluated before and after 14-weeks of intervention. Plasma levels of interleukin (IL)-1\u03b2, IL-1ra, IL-6, IL-10, IL-17, tumor necrosis factor alpha (TNF-\u03b1), and serum concentration of S100\u03b2 and neuron specific enolase (NSE) were determined. The mini mental state examination (MMSE) was also applied. Concentrations of S100\u03b2 were maintained in all intervention groups, while a subtle increase in the CG was found. NSE levels increased only in TAU group (p &lt; 0.05). CET reduced TNF-\u03b1, IL-6, and IL-1\u03b2\/IL-1ra, IL-6\/IL10, and TNF-\u03b1\/IL-10 ratios (p &lt; 0.05). TAU decreased the IL-1\u03b2\/IL-1ra ratio (p &lt; 0.05). MMSE score increased only in the CET+TAU group (p &lt; 0.05). Multiple regression analysis showed that there was a trend for changes in IL-1\u03b2 and the Charlson Comorbidity Index to be independently associated with changes in S100\u03b2. Exercise and taurine decreased inflammation, and maintained the BBB integrity in elderly women. Exercise emerged as an important tool to improve brain health even when started at advanced ages. <\/jats:p>","DOI":"10.1139\/apnm-2017-0775","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T17:36:40Z","timestamp":1519407400000},"page":"733-741","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":70,"title":["Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women"],"prefix":"10.1139","volume":"43","author":[{"given":"Matheus Uba","family":"Chupel","sequence":"first","affiliation":[{"name":"Faculty of Sport Science and Physical Education, University of Coimbra, Est\u00e1dio Universit\u00e1rio de Coimbra, Avenida Con\u00edmbriga, Pavilh\u00e3o 3. 3040-248, Coimbra, Portugal."}]},{"given":"Luciele Guerra","family":"Minuzzi","sequence":"additional","affiliation":[{"name":"Faculty of Sport Science and Physical Education, University of Coimbra, Est\u00e1dio Universit\u00e1rio de Coimbra, Avenida Con\u00edmbriga, Pavilh\u00e3o 3. 3040-248, Coimbra, Portugal."}]},{"given":"Guilherme","family":"Furtado","sequence":"additional","affiliation":[{"name":"Faculty of Sport Science and Physical Education, University of Coimbra, Est\u00e1dio Universit\u00e1rio de Coimbra, Avenida Con\u00edmbriga, Pavilh\u00e3o 3. 3040-248, Coimbra, Portugal."}]},{"given":"M\u00e1rio Leonardo","family":"Santos","sequence":"additional","affiliation":[{"name":"Faculty of Sport Science and Physical Education, University of Coimbra, Est\u00e1dio Universit\u00e1rio de Coimbra, Avenida Con\u00edmbriga, Pavilh\u00e3o 3. 3040-248, Coimbra, Portugal."}]},{"given":"Eef","family":"Hogervorst","sequence":"additional","affiliation":[{"name":"Applied Cognitive Research NCSEM Loughborough University, Loughborough, UK Epinal Way, Loughborough, LE11 3TU, Leicestershire, UK."}]},{"given":"Edith","family":"Filaire","sequence":"additional","affiliation":[{"name":"CIAMS, Universit\u00e9 d\u2019Orl\u00e9ans, Orl\u00e9ans, France."},{"name":"CIAMS, Universit\u00e9 Paris-Sud, Universit\u00e9 Paris-Saclay, Orsay, France."},{"name":"UMR 1019, INRA, Equipe ECREIN UNH, Clermont-Ferrand, France. 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