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H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> is a ROS with an important role in cell signaling, but how H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> regulates tumor angiogenesis is still poorly understood. We have xenografted tumor cells with altered levels of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> by catalase overexpression into zebrafish embryos to study redox-induced tumor neovascularization. We found that vascular recruitment and invasion were impaired if catalase was overexpressed. In addition, the overexpression of catalase altered the transcriptional levels of several angiogenesis-related factors in tumor cells, including TIMP-3 and THBS1. These two anti-angiogenic factors were found to be H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>-regulated by two different mechanisms: TIMP-3 expression in a cell-autonomous manner; and, THBS1 expression that was non-cell-autonomous. Our work shows that intracellular H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> regulates the expression of angiogenic factors and the formation of a vessel network. Understanding the molecular mechanisms that govern this multifunctional effect of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> on tumor angiogenesis could be important for the development of more efficient anti-angiogenic therapies. <\/jats:p>","DOI":"10.1139\/bcb-2017-0083","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T21:38:36Z","timestamp":1503005916000},"page":"679-685","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Hydrogen peroxide regulates angiogenesis-related factors in tumor cells"],"prefix":"10.1139","volume":"95","author":[{"given":"Ana","family":"Jer\u00f3nimo","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal."}]},{"given":"Gon\u00e7alo","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica e 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