{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:19:36Z","timestamp":1777382376314,"version":"3.51.4"},"reference-count":20,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Microbiol."],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p> Aspergillus fumigatus conidia have been linked to severe aspergillosis in immunocompromised patients. Recently, the cytotoxic effect of secondary metabolites from A. fumigatus conidia was reported. In the present work, a methodology used to detect cell death markers in fungal hyphae was adapted to study conidia cell death. Additionally, the mechanism of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>-induced cell death was studied in A. fumigatus conidia for the first time. Data presented in this work reveal that the H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>-induced conidial cell death was associated with a marked increase of TUNEL- and PI-positive cells. It is therefore suggested that conidia cell death occurs in a dose-dependent manner through a secondary necrosis mechanism. The knowledge of conidia cell death machinery may provide insights into the molecular mechanism of conidia-mediated toxicity to the respiratory tract and may pave the way for improved therapeutic approaches against A. fumigatus conidia-mediated diseases. <\/jats:p>","DOI":"10.1139\/cjm-2015-0561","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T22:38:20Z","timestamp":1447799900000},"page":"95-101","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Hydrogen peroxide-induced secondary necrosis in conidia of <i>Aspergillus fumigatus<\/i>"],"prefix":"10.1139","volume":"62","author":[{"given":"M.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade Do Porto, Portugal."},{"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal."},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Porto, Portugal."}]},{"given":"C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"UCIBIO\/REQUIMTE, Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228; 4050-313 Porto, Portugal."}]},{"given":"C.","family":"Bessa","sequence":"additional","affiliation":[{"name":"UCIBIO\/REQUIMTE, Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228; 4050-313 Porto, Portugal."}]},{"given":"R.","family":"Araujo","sequence":"additional","affiliation":[{"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal."}]},{"given":"L.","family":"Saraiva","sequence":"additional","affiliation":[{"name":"UCIBIO\/REQUIMTE, Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228; 4050-313 Porto, Portugal."}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15b30.x"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-112"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2010.04.009"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00055-08"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029906"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2240"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2008.03.003"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05872.x"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-147-9-2409"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E01-12-0161"},{"key":"refg11\/ref11","unstructured":"Macher, J.M., Douwes, J., Prezant, B., and Reponen, T. 2012. 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