{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T12:30:56Z","timestamp":1697545856365},"reference-count":27,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[1999,8,1]],"date-time":"1999-08-01T00:00:00Z","timestamp":933465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Fish. Aquat. Sci."],"published-print":{"date-parts":[[1999,8,1]]},"abstract":"<jats:p> In this study, the time-dependent P450 response to oral benzo[a]pyrene exposure at 1 and 10\u00b0C was investigated in winter- and summer-acclimated Arctic char (Salvelinus alpinus). In both seasons, a strong induction of CYP1A activities and protein levels (measured only in the winter experiment) were seen at both 1 and 10\u00b0C. At 1\u00b0C, the responses were delayed and more long-lasting than at 10\u00b0C. No within-season difference between 1 and 10\u00b0C in the magnitude of the induction response was found, but due to elevated baseline CYP1A activities, the induction response was seven times lower in winter- as compared with the response in summer-acclimated Arctic char. The results show that the CYP1A enzymes of the Arctic char respond to temperature changes in a compensatory way, and they are promising with respect to the applicability of the P450 enzyme system of the Arctic char as a biomarker for monitoring polycyclic aromatic hydrocarbon contamination in high-latitude environments. More studies are needed, however, to reveal seasonal differences in the biomarker response to pollutants. <\/jats:p>","DOI":"10.1139\/f99-075","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T22:46:57Z","timestamp":1303685217000},"page":"1370-1375","source":"Crossref","is-referenced-by-count":2,"title":["Effect of temperature on the P4501A response in winter- and summer-acclimated Arctic char (<i>Salvelinus alpinus<\/i>) after oral benzo[a]pyrene exposure"],"prefix":"10.1139","volume":"56","author":[{"given":"Even H","family":"J\u00f8rgensen","sequence":"first","affiliation":[]},{"given":"Johannes","family":"Wolkers","sequence":"additional","affiliation":[]}],"member":"155","reference":[{"key":"p_1\/p_1_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0166-445X(92)90014-E","volume":"24","author":"Andersson T.","year":"1992","journal-title":"Aquat. 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