{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:41:38Z","timestamp":1760121698781},"reference-count":40,"publisher":"Canadian Science Publishing","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Microbiol."],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p>Streptococcus agalactiae is a common pathogen that causes bovine mastitis. The aims of this study were to evaluate the antibody response against S. agalactiae extracellular proteins in the whey and serum of naturally infected bovines and to identify possible immunodominant extracellular antigens. IgG<jats:sub>1<\/jats:sub>antibodies against S. agalactiae extracellular proteins were elevated in the whey and serum of naturally infected bovines. In the whey, the levels of IgG<jats:sub>1<\/jats:sub>specific for S.\u00a0agalactiae extracellular proteins were similar in infected and noninfected milk quarters from the same cow, and the production of antibodies specific for S. agalactiae extracellular proteins was induced only by infection with this bacterium. The immunoreactivity of extracellular proteins with bovine whey was clearly different in infected versus control animals. Group B protective surface protein and 5\u2032-nucleotidase family protein were 2 major immunoreactive proteins that were detected only in the whey of infected cows, suggesting that these proteins may be important in the pathogenesis of S.\u00a0agalactiae-induced mastitis. This information could be used to diagnose S. agalactiae infection. In addition, these antigens may be useful as carrier proteins for serotype-specific polysaccharides in conjugate vaccines.<\/jats:p>","DOI":"10.1139\/w08-083","type":"journal-article","created":{"date-parts":[[2008,11,7]],"date-time":"2008-11-07T16:36:18Z","timestamp":1226075778000},"page":"899-905","source":"Crossref","is-referenced-by-count":6,"title":["Identification of immunoreactive extracellular proteins of Streptococcus agalactiae in bovine mastitis"],"prefix":"10.1139","volume":"54","author":[{"given":"Gabriela","family":"Trigo","sequence":"first","affiliation":[{"name":"ICBAS\u00a0\u2013 Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Universidade do Porto, Largo Prof. Abel Salazar 2, 4099-003 Porto, Portugal."},{"name":"IBMC\u00a0\u2013 Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal."},{"name":"Segalab S.A. 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