{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T02:26:22Z","timestamp":1656728782211},"reference-count":43,"publisher":"Canadian Science Publishing","issue":"11","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2004,11,1]]},"abstract":"<jats:p>The aim of this work was to characterize the mucosal-to-serosal (apical to basolateral; AP-BL) and serosal-to-mucosal (basolateral to apical; BL-AP) transport of serotonin (5-HT) across rat jejunum, ileum, and colon, and to determine the influence of serotonin neuronal transporter inhibitors on this transport. The AP-BL apparent permeability (P<jats:sub>app<\/jats:sub>) of<jats:sup>3<\/jats:sup>H-5-HT increased in the order colon\u2002=\u2002jejunum &lt; ileum, and the BL-AP P<jats:sub>app<\/jats:sub>of<jats:sup>3<\/jats:sup>H-5-HT increased in the order colon &lt; jejunum\u2002=\u2002ileum. In vitro, neither fluoxetine (0.02 or 0.2 \u00b5mol\/L) nor desipramine (0.4 or 4 \u00b5mol\/L) had a significant effect upon the AP-BL or BL-AP P<jats:sub>app<\/jats:sub>of<jats:sup>3<\/jats:sup>H-5-HT in any of the intestinal regions. However, fluoxetine (0.2 \u00b5mol\/L) decreased the accumulation of<jats:sup>3<\/jats:sup>H-5-HT in the ileum (to 65% of control) in the BL-AP experiments. In vivo, chronic fluoxetine (10 mg\/kg daily administered orally for 15 days), as assessed in the ileum, significantly increased (to \u00b1180% of control levels) the BL-AP P<jats:sub>app<\/jats:sub>of<jats:sup>3<\/jats:sup>H-5-HT and tended to increase the AP-BL P<jats:sub>app<\/jats:sub>of<jats:sup>3<\/jats:sup>H-5-HT. In conclusion, the increase in the P<jats:sub>app<\/jats:sub>of<jats:sup>3<\/jats:sup>H-5-HT after chronic administration of fluoxetine suggests that this treatment is able to increase the extracellular concentration of<jats:sup>3<\/jats:sup>H-5-HT at the intestinal level.Key words: fluoxetine, serotonin, rat intestine, permeability.<\/jats:p>","DOI":"10.1139\/y04-083","type":"journal-article","created":{"date-parts":[[2005,2,16]],"date-time":"2005-02-16T20:35:50Z","timestamp":1108586150000},"page":"940-950","source":"Crossref","is-referenced-by-count":8,"title":["In vitro and in vivo effect of fluoxetine on the permeability of<sup>3<\/sup>H-serotonin across rat intestine"],"prefix":"10.1139","volume":"82","author":[{"given":"F\u00e1tima","family":"Martel","sequence":"first","affiliation":[]},{"given":"Ros\u00e1rio","family":"Monteiro","sequence":"additional","affiliation":[]},{"given":"Clara","family":"Lemos","sequence":"additional","affiliation":[]},{"given":"M A","family":"Vieira-Coelho","sequence":"additional","affiliation":[]}],"member":"155","reference":[{"key":"p_1\/p_1_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1748-1716.1981.tb06815.x","volume":"112","author":"Ahlman H.","year":"1981","journal-title":"Acta Physiol. 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