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An in-air irradiation set-up was developed that allows energy tuning and enables estimating the flux and dose deposition in cells. A pilot study on the effect of boron-rich metallacarboranes as radiosensitizers towards human glioblastoma cells was carried out. This served as a proof of concept for the enhancement effect of proton irradiation induced by the presence of boron, which undergoes a nuclear <jats:sup>11<\/jats:sup>B(p,<jats:italic>\u03b1<\/jats:italic>)<jats:italic>\u03b1\u03b1<\/jats:italic> reaction. Details of the experimental set-up and physical parameters measured are presented. 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