{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T01:38:00Z","timestamp":1722821880656},"reference-count":15,"publisher":"World Scientific Pub Co Pte Lt","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Found. Comput. Sci."],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p> In this article, we model a linkage disequilibrium study (genomic study) as an optimization problem where a given objective function has to be optimized. The objective of the study is to discover haplotypes (associations of genetic markers) candidate to explain multi-factorial diseases such as diabetes or obesity. To determine what kind of algorithm will be able to solve this problem, we first study the specificities and the structure of the problem. Results of this study show that exact algorithms are not adapted to this specific problem and lead us to the development of a parallel dedicated adaptive multipopulation genetic algorithm that is able to find several haplotypes of different sizes. After describing the genomic problem, we present the dedicated genetic algorithm, its specificities, such as the use of several populations and its advanced mechanisms such as the adaptive choice of operators, random immigrants, and its parallel implementation. Results on a real dataset are given. <\/jats:p>","DOI":"10.1142\/s0129054105002978","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T11:12:19Z","timestamp":1114600339000},"page":"241-260","source":"Crossref","is-referenced-by-count":4,"title":["LINKAGE DISEQUILIBRIUM STUDY WITH A PARALLEL ADAPTIVE <font>GA<\/font>"],"prefix":"10.1142","volume":"16","author":[{"given":"L.","family":"VERMEULEN-JOURDAN","sequence":"first","affiliation":[{"name":"LIFL, B\u00e2timent M3, Cit\u00e9 scientifique,  59655 Villeneuve d'Ascq Cedex, France"}]},{"given":"C.","family":"DHAENENS","sequence":"additional","affiliation":[{"name":"LIFL, B\u00e2timent M3, Cit\u00e9 scientifique,  59655 Villeneuve d'Ascq Cedex, France"}]},{"given":"E-G.","family":"TALBI","sequence":"additional","affiliation":[{"name":"LIFL, B\u00e2timent M3, Cit\u00e9 scientifique,  59655 Villeneuve d'Ascq Cedex, France"}]}],"member":"219","published-online":{"date-parts":[[2011,11,20]]},"reference":[{"key":"rf1","first-page":"67","author":"Boichard D.","journal-title":"INRA Production Animale"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.2001.6510095.x"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0419"},{"key":"rf5","first-page":"97","author":"Sham P. C.","journal-title":"Annal Human Genetic"},{"key":"rf6","doi-asserted-by":"crossref","DOI":"10.7551\/mitpress\/5712.001.0001","volume-title":"PVM: Parallel Virtual Machine - A User's Guide and Tutorial for Networked Parallel Computing","author":"Geist A.","year":"1994"},{"key":"rf7","volume-title":"Genetic Algorithms - in Search, Optimization and Machine Learning","author":"Goldberg D. E.","year":"1989"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009642825198"},{"key":"rf9","doi-asserted-by":"crossref","unstructured":"L.\u00a0Jourdan, C.\u00a0Dhaenens and E.G.\u00a0Talbi, Evolutionary Computation in Bioinformatic (Morgan Kaufmann, 2002)\u00a0pp. 297\u2013316.","DOI":"10.1016\/B978-155860797-2\/50016-0"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.1086\/301678"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1101\/gr.194801"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/18.6.894"},{"key":"rf14","author":"Terwilliger J. D.","journal-title":"Am. J. Hum. Genet."},{"key":"rf15","volume-title":"Handbook of human genetic linkage","author":"Terwilliger J. D.","year":"1994"},{"key":"rf17","doi-asserted-by":"publisher","DOI":"10.1086\/302954"},{"key":"rf18","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-5725-8_8"}],"container-title":["International Journal of Foundations of Computer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0129054105002978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T15:27:03Z","timestamp":1565191623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0129054105002978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":15,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2011,11,20]]},"published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1142\/S0129054105002978"],"URL":"https:\/\/doi.org\/10.1142\/s0129054105002978","relation":{},"ISSN":["0129-0541","1793-6373"],"issn-type":[{"value":"0129-0541","type":"print"},{"value":"1793-6373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}