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Our methodology enables the assembly of cell systems biology models by combining modules which represent functional subsystems. A case study consisting of a bacterial colony system is presented to illustrate our approach.<\/jats:p>","DOI":"10.1142\/s0129054109006668","type":"journal-article","created":{"date-parts":[[2009,6,3]],"date-time":"2009-06-03T11:16:30Z","timestamp":1244027790000},"page":"427-442","source":"Crossref","is-referenced-by-count":31,"title":["MODULAR ASSEMBLY OF CELL SYSTEMS BIOLOGY MODELS USING<font>P<\/font>SYSTEMS"],"prefix":"10.1142","volume":"20","author":[{"given":"FRANCISCO J.","family":"ROMERO-CAMPERO","sequence":"first","affiliation":[{"name":"Automated Scheduling, Optimisation and Planning Research Group, School of Computer Science, Jubilee Campus, University of Nottingham, Nottingham NG8 1BB, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAMIE","family":"TWYCROSS","sequence":"additional","affiliation":[{"name":"Centre for Plant Integrative Biology, Sutton Bonington Campus, University of Nottingham, LE12 5RD, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIGUEL","family":"C\u00c1MARA","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation, Center for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MALCOLM","family":"BENNETT","sequence":"additional","affiliation":[{"name":"Centre for Plant Integrative Biology, Sutton Bonington Campus, University of Nottingham, LE12 5RD, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIAN","family":"GHEORGHE","sequence":"additional","affiliation":[{"name":"Department of Computer Science, The University of Sheffield, Regent Court, Portobello Street, Sheffield S1 4DP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NATALIO","family":"KRASNOGOR","sequence":"additional","affiliation":[{"name":"Automated Scheduling, Optimisation and Planning Research Group, School of Computer Science, Jubilee Campus, University of Nottingham, Nottingham NG8 1BB, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,30]]},"reference":[{"key":"rf1","series-title":"Mathematical and Computational Biology Series","doi-asserted-by":"crossref","DOI":"10.1201\/9781420011432","volume-title":"An Introduction to Systems Biology","author":"Alon U.","year":"2006"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1637"},{"key":"rf3","first-page":"509","volume":"10","author":"Bernardini F.","journal-title":"Journal of Universal Computer Science"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-77312-2_9"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcs.2006.10.012"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcs.2007.03.044"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.08.045"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1038\/nature05127"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1356"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.1007\/11603047_14"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbl043"},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physchem.58.032806.104637"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.12.6750"},{"key":"rf14","doi-asserted-by":"publisher","DOI":"10.1038\/35011540"},{"key":"rf15","first-page":"135","volume":"85","author":"Krasnogor N.","journal-title":"Bulletin of the EATCS"},{"key":"rf16","doi-asserted-by":"publisher","DOI":"10.1145\/1059816.1059820"},{"key":"rf18","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3975(02)00659-X"},{"key":"rf19","first-page":"176","author":"P\u00e9rez-Jim\u00e9nez M. 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