{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:31:57Z","timestamp":1772069517075,"version":"3.50.1"},"reference-count":66,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Neur. Syst."],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p> Organized brain activity is the result of dynamical, segregated neuronal signals that may be used to investigate synchronization effects using sophisticated neuroengineering techniques. Phase synchrony analysis, in particular, has emerged as a promising methodology to study transient and frequency-specific coupling effects across multi-site signals. In this study, we investigated phase synchronization in intracellular recordings of interictal and ictal epileptiform events recorded from pairs of cells in the whole (intact) mouse hippocampus. In particular, we focused our analysis on the background noise-like activity (NLA), previously reported to exhibit complex neurodynamical properties. Our results show evidence for increased linear and nonlinear phase coupling in NLA across three frequency bands [theta (4\u201310 Hz), beta (12\u201330 Hz) and gamma (30\u201380 Hz)] in the ictal compared to interictal state dynamics. We also present qualitative and statistical evidence for increased phase synchronization in the theta, beta and gamma frequency bands from paired recordings of ictal NLA. Overall, our results validate the use of background NLA in the neurodynamical study of epileptiform transitions and suggest that what is considered \"neuronal noise\" is amenable to synchronization effects in the spatiotemporal domain. <\/jats:p>","DOI":"10.1142\/s0129065712500335","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T08:59:17Z","timestamp":1349773157000},"page":"1250033","source":"Crossref","is-referenced-by-count":16,"title":["PHASE SYNCHRONIZATION OF NEURONAL NOISE IN MOUSE HIPPOCAMPAL EPILEPTIFORM DYNAMICS"],"prefix":"10.1142","volume":"23","author":[{"given":"DEMITRE","family":"SERLETIS","sequence":"first","affiliation":[{"name":"Neurological Institute, Epilepsy Center, Cleveland Clinic, Ohio 44195, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER L.","family":"CARLEN","sequence":"additional","affiliation":[{"name":"Division of Neurology, Toronto Western Hospital, Ontario M5T 2S8, Canada"},{"name":"Department of Physiology, University of Toronto, Ontario M5S 1A8, Canada"},{"name":"Institute of Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAUFIK A.","family":"VALIANTE","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital, Ontario M5T 2S8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BERJ L.","family":"BARDAKJIAN","sequence":"additional","affiliation":[{"name":"Institute of Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5S 3G9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,12,30]]},"reference":[{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.05.006"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2003.810705"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1046-05.2005"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1038\/2610"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2003.810689"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2011.07.004"},{"key":"rf8","doi-asserted-by":"crossref","DOI":"10.7551\/mitpress\/3626.001.0001","volume-title":"I of the Vortex: From Neurons to Self","author":"Llin\u00e1s R. 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