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The system was developed using statistical leave-one-patient-out performance assessment, on a large clinical dataset, comprising 38 patients of 1479 h total duration. The developed technique was then validated by a single test on a separate totally unseen randomized prospective dataset of 51 neonates totaling 2540 h of duration. By exploiting the proposed adaptation, the ROC area is increased from 93.4% to 96.1% (41% relative improvement). The number of false detections per hour is decreased from 0.42 to 0.24, while maintaining the correct detection of seizure burden at 70%. These results on the unseen data were predicted from the rigorous leave-one-patient-out validation and confirm the validity of our algorithm development process. <\/jats:p>","DOI":"10.1142\/s0129065713500184","type":"journal-article","created":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T02:08:49Z","timestamp":1366337329000},"page":"1350018","source":"Crossref","is-referenced-by-count":58,"title":["ROBUST NEONATAL EEG SEIZURE DETECTION THROUGH ADAPTIVE BACKGROUND MODELING"],"prefix":"10.1142","volume":"23","author":[{"given":"ANDRIY","family":"TEMKO","sequence":"first","affiliation":[{"name":"Neonatal Brain Research Group, Department of Electrical and Electronic Engineering, University College Cork, Ireland"}]},{"given":"GERALDINE","family":"BOYLAN","sequence":"additional","affiliation":[{"name":"Neonatal Brain Research Group, Department of Paediatrics and Child Health, University College Cork, Ireland"}]},{"given":"WILLIAM","family":"MARNANE","sequence":"additional","affiliation":[{"name":"Neonatal Brain Research Group, Department of Electrical and Electronic Engineering, University College Cork, Ireland"}]},{"given":"GORDON","family":"LIGHTBODY","sequence":"additional","affiliation":[{"name":"Neonatal Brain Research Group, Department of Electrical and Electronic Engineering, University College Cork, Ireland"}]}],"member":"219","published-online":{"date-parts":[[2013,6,9]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.068551"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.086314"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.01.043"},{"key":"rf4","first-page":"464","volume":"122","author":"Temko A.","journal-title":"Clin. 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