{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:14:36Z","timestamp":1776374076665,"version":"3.51.2"},"reference-count":91,"publisher":"World Scientific Pub Co Pte Ltd","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Neur. Syst."],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>In the present study, both single channel electroencephalography (EEG) complexity and two channel interhemispheric dependency measurements have newly been examined for classification of patients with obsessive\u2013compulsive disorder (OCD) and controls by using support vector machine classifiers. Three embedding entropy measurements (approximate entropy, sample entropy, permutation entropy (PermEn)) are used to estimate single channel EEG complexity for 19-channel eyes closed cortical measurements. Mean coherence and mutual information are examined to measure the level of interhemispheric dependency in frequency and statistical domain, respectively for eight distinct electrode pairs placed on the scalp with respect to the international 10\u201320 electrode placement system. All methods are applied to short EEG segments of 2 s. The classification performance is measured 20 times with different 2-fold cross-validation data for both single channel complexity features (19 features) and interhemispheric dependency features (eight features). The highest classification accuracy of 85 \u00b15.2% is provided by PermEn at prefrontal regions of the brain. Even if the classification success do not provided by other methods as high as PermEn, the clear differences between patients and controls at prefrontal regions can also be obtained by using other methods except coherence. In conclusion, OCD, defined as illness of orbitofronto-striatal structures [Beucke et al., JAMA Psychiatry 70 (2013) 619\u2013629; Cavedini et al., Psychiatry Res. 78 (1998) 21\u201328; Menzies et al., Neurosci. Biobehav. Rev. 32(3) (2008) 525\u2013549], is caused by functional abnormalities in the pre-frontal regions. Particularly, patients are characterized by lower EEG complexity at both pre-frontal regions and right fronto-temporal locations. Our results are compatible with imaging studies that define OCD as a sub group of anxiety disorders exhibited a decreased complexity (such as anorexia nervosa [Toth et al., Int. J. Psychophysiol. 51(3) (2004) 253\u2013260] and panic disorder [Bob et al., Physiol. Res. 55 (2006) S113\u2013S119]).<\/jats:p>","DOI":"10.1142\/s0129065715500100","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T08:13:40Z","timestamp":1424938420000},"page":"1550010","source":"Crossref","is-referenced-by-count":72,"title":["Classification of Obsessive Compulsive Disorder by EEG Complexity and Hemispheric Dependency Measurements"],"prefix":"10.1142","volume":"25","author":[{"given":"Serap","family":"Aydin","sequence":"first","affiliation":[{"name":"Biomedical Engineering Department, Bah\u00e7e\u015fehir University, Be\u015fikta\u015f Istanbul 34353, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafiz","family":"Arica","sequence":"additional","affiliation":[{"name":"Software Engineering Department, Bah\u00e7e\u015fehir University, Be\u015fikta\u015f Istanbul 34353, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emrah","family":"Ergul","sequence":"additional","affiliation":[{"name":"Electronics and Communications Engineering Department, Kocaeli University, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O\u011fuz","family":"Tan","sequence":"additional","affiliation":[{"name":"Uskudar University, Neuropsychiatry Health, Practice and Research Center Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2015,4,8]]},"reference":[{"key":"rf1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"Arlington V. 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