{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T13:57:38Z","timestamp":1761400658343},"reference-count":67,"publisher":"World Scientific Pub Co Pte Lt","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Neur. Syst."],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p> Interictal epileptiform discharges (IEDs) are transient neural electrical activities that occur in the brain of patients with epilepsy. A problem with the inspection of IEDs from the scalp electroencephalogram (sEEG) is that for a subset of epileptic patients, there are no visually discernible IEDs on the scalp, rendering the above procedures ineffective, both for detection purposes and algorithm evaluation. On the other hand, intracranially placed electrodes yield a much higher incidence of visible IEDs as compared to concurrent scalp electrodes. In this work, we utilize concurrent scalp and intracranial EEG (iEEG) from a group of temporal lobe epilepsy (TLE) patients with low number of scalp-visible IEDs. The aim is to determine whether by considering the timing information of the IEDs from iEEG, the resulting concurrent sEEG contains enough information for the IEDs to be reliably distinguished from non-IED segments. We develop an automatic detection algorithm which is tested in a leave-subject-out fashion, where each test subject\u2019s detection algorithm is based on the other patients\u2019 data. The algorithm obtained a [Formula: see text] accuracy in recognizing scalp IED from non-IED segments with [Formula: see text] accuracy when trained and tested on the same subject. Also, it was able to identify nonscalp-visible IED events for most patients with a low number of false positive detections. Our results represent a proof of concept that IED information for TLE patients is contained in scalp EEG even if they are not visually identifiable and also that between subject differences in the IED topology and shape are small enough such that a generic algorithm can be used. <\/jats:p>","DOI":"10.1142\/s0129065716500167","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T05:31:12Z","timestamp":1455168672000},"page":"1650016","source":"Crossref","is-referenced-by-count":32,"title":["Detection of Intracranial Signatures of Interictal Epileptiform Discharges from Concurrent Scalp EEG"],"prefix":"10.1142","volume":"26","author":[{"given":"Loukianos","family":"Spyrou","sequence":"first","affiliation":[{"name":"Department of Computer Science, University of Surrey, UK"}]},{"given":"David","family":"Mart\u00edn-Lopez","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, UK"},{"name":"Department of Clinical Neurophysiology, King\u2019s College Hospital NHS FT, London, UK"},{"name":"Department of Clinical Neurophysiology, Ashford and St Peter\u2019s Hospital NHS FT, Chertsey, UK"},{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Complutense, Madrid, Spain"}]},{"given":"Antonio","family":"Valent\u00edn","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, UK"},{"name":"Department of Clinical Neurophysiology, King\u2019s College Hospital NHS FT, London, UK"},{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Complutense, Madrid, Spain"}]},{"given":"Gonzalo","family":"Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, UK"},{"name":"Department of Clinical Neurophysiology, King\u2019s College Hospital NHS FT, London, UK"},{"name":"Comprehensive Epilepsy Center Neuroscience Institute, Academic Health Systems, Hamad Medical Corporation, Doha, Qatar"}]},{"given":"Saeid","family":"Sanei","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Surrey, UK"}]}],"member":"219","published-online":{"date-parts":[[2016,4,27]]},"reference":[{"key":"S0129065716500167BIB001","doi-asserted-by":"publisher","DOI":"10.1002\/9781118622162"},{"key":"S0129065716500167BIB002","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1970.tb03903.x"},{"key":"S0129065716500167BIB003","volume-title":"A Textbook of Epilepsy","author":"Binnie C.","year":"1992"},{"issue":"5","key":"S0129065716500167BIB004","first-page":"64","volume":"22","author":"Kumar R.","year":"2013","journal-title":"Int. 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