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We found biomarkers for checking the efficacy of VNS with accuracy up to 94%. The results show that P300 features recorded in nonmidline electrodes are better P300 biomarkers for VNS efficacy than P300 features recorded in midline electrodes. Using source localization and connectivity analyses, the activity of the limbic system, insula and orbitofrontal cortex was found to be dependent on VNS switched \u201cOn\u201d versus \u201cOff\u201d or patient group (R versus NR). The results suggest an important role for these areas in the mechanism of action of VNS, although a larger patient study should be done to confirm the findings. <\/jats:p>","DOI":"10.1142\/s0129065716500489","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T23:43:10Z","timestamp":1468280590000},"page":"1650048","source":"Crossref","is-referenced-by-count":27,"title":["EEG Derived Brain Activity Reflects Treatment Response from Vagus Nerve Stimulation in Patients with Epilepsy"],"prefix":"10.1142","volume":"27","author":[{"given":"Simon","family":"Wostyn","sequence":"first","affiliation":[{"name":"MEDISIP, Department of Electronics and Information Systems, Ghent University, Ghent, Belgium"},{"name":"iMinds Medical IT Department, Ghent University, Ghent, Belgium"}]},{"given":"Willeke","family":"Staljanssens","sequence":"additional","affiliation":[{"name":"MEDISIP, Department of Electronics and Information Systems, Ghent University, Ghent, 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