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Functional connectivity within and between five networks, corresponding to seizure origination and cognitive processes, were analyzed to measure IED effects. We found that patients exhibited increased connectivity within the auditory network (AN) and the somato-motor network (SMN), and decreased connectivity within the basal ganglia network and the dorsal attention network, suggesting that both transient and chronic seizure activity may disturb normal network organization. The IED group showed decreased functional connectivity within the default mode network (DMN) compared with the non-IED group and HCs, implying that the DMN was selectively impaired during epileptiform discharges associated with altered self-referential cognitive functions. Moreover, the IED group exhibited increased positive correlations between the AN and the SMN, which suggests a possible excessive influence of centrotemporal spiking on information processing in the auditory system. The association between epileptic activity and network dysfunctions highlights their importance in investigating the pathological mechanism underlying BECTS.<\/jats:p>","DOI":"10.1142\/s0129065717500186","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T10:14:32Z","timestamp":1484043272000},"page":"1750018","source":"Crossref","is-referenced-by-count":49,"title":["Epileptic Discharge Related Functional Connectivity Within and Between Networks in Benign Epilepsy with Centrotemporal Spikes"],"prefix":"10.1142","volume":"27","author":[{"given":"Rong","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in BioMedicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China"}]},{"given":"Gong-Jun","family":"Ji","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei 230000, P. R. China"}]},{"given":"Yangyang","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in BioMedicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, the Second Affiliated Hospital of Medial College, Zhejiang University, Zhejiang 310009, P. R. China"}]},{"given":"Mei-Ping","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Second Affiliated Hospital of Medial College, Zhejiang University, Zhejiang 310009, P. R. China"}]},{"given":"Ye-Lei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Second Affiliated Hospital of Medial College, Zhejiang University, Zhejiang 310009, P. R. China"}]},{"given":"Huafu","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in BioMedicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China"}]},{"given":"Wei","family":"Liao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in BioMedicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, P. R. 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