{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:01:19Z","timestamp":1771635679156,"version":"3.50.1"},"reference-count":33,"publisher":"World Scientific Pub Co Pte Lt","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Neur. Syst."],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p> Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a promising treatment for patients with refractory epilepsy. However, therapy response varies and precise positioning of the DBS lead is potentially essential for maximizing therapeutic efficacy. We investigate if single-cell recordings acquired by microelectrode recordings can aid targeting of the ANT during surgery and hypothesize that the neuronal firing properties of the target region relate to clinical outcome. We prospectively included 10 refractory epilepsy patients and performed microelectrode recordings under general anesthesia to identify the change in neuronal signals when approaching and transecting the ANT. The neuronal firing properties of the target region, anatomical locations of microelectrode recordings and active contact positions of the DBS lead along the recorded trajectory were compared between responders and nonresponders to DBS. We obtained 19 sets of recordings from 10 patients (five responders and five nonresponders). Amongst the 403 neurons detected, 365 (90.6%) were classified as bursty. Entry into the ANT was characterized by an increase in firing rate while exit of the ANT was characterized by a decrease in firing rate. Comparing the trajectories of responders to nonresponders, we found differences neither in the neuronal firing properties themselves nor in their locations relative to the position of the active contact. Single-cell firing rate acquired by microelectrode recordings under general anesthesia can thus aid targeting of the ANT during surgery, but is not related to clinical outcome in DBS for patients with refractory epilepsy. <\/jats:p>","DOI":"10.1142\/s0129065718500120","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T12:19:45Z","timestamp":1522671585000},"page":"1850012","source":"Crossref","is-referenced-by-count":31,"title":["Single-Cell Recordings to Target the Anterior Nucleus of the Thalamus in Deep Brain Stimulation for Patients with Refractory Epilepsy"],"prefix":"10.1142","volume":"29","author":[{"given":"Fr\u00e9d\u00e9ric L. W. V. J.","family":"Schaper","sequence":"first","affiliation":[{"name":"Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands"},{"name":"Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands"},{"name":"School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Biomedical Signals and Systems Group, Department of Electrical Engineering, Mathematics and Computer Science, MIRA Institute for Biomedical Engineering and Technical Medicine, University of Twente, Enschede, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus L. F.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands"},{"name":"School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Louis","family":"Wagner","sequence":"additional","affiliation":[{"name":"Academic Center for Epileptology, Epilepsy Center Kempenhaeghe\/Maastricht, University Medical Center, Oosterhout, Heeze and Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert J.","family":"Colon","sequence":"additional","affiliation":[{"name":"Academic Center for Epileptology, Epilepsy Center Kempenhaeghe\/Maastricht, University Medical Center, Oosterhout, Heeze and Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny M. W.","family":"Hilkman","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Gommer","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00eblle C. G.","family":"Vlooswijk","sequence":"additional","affiliation":[{"name":"Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands"},{"name":"Academic Center for Epileptology, Epilepsy Center Kempenhaeghe\/Maastricht, University Medical Center, Oosterhout, Heeze and Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Govert","family":"Hoogland","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands"},{"name":"School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Ackermans","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lo J.","family":"Bour","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J. A.","family":"Van Wezel","sequence":"additional","affiliation":[{"name":"Biomedical Signals and Systems Group, Department of Electrical Engineering, Mathematics and Computer Science, MIRA Institute for Biomedical Engineering and Technical Medicine, University of Twente, Enschede, The Netherlands"},{"name":"Biophysics Group, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Boon","sequence":"additional","affiliation":[{"name":"Academic Center for Epileptology, Epilepsy Center Kempenhaeghe\/Maastricht, University Medical Center, Oosterhout, Heeze and Maastricht, The Netherlands"},{"name":"Department of Neurology, University Hospital Ghent, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasin","family":"Temel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands"},{"name":"School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjitske","family":"Heida","sequence":"additional","affiliation":[{"name":"Biomedical Signals and Systems Group, Department of Electrical Engineering, Mathematics and Computer Science, MIRA Institute for Biomedical Engineering and Technical Medicine, University of Twente, Enschede, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivianne H. J. M.","family":"Van Kranen-Mastenbroek","sequence":"additional","affiliation":[{"name":"Academic Center for Epileptology, Epilepsy Center Kempenhaeghe\/Maastricht, University Medical Center, Oosterhout, Heeze and Maastricht, The Netherlands"},{"name":"Department of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, The Netherlands"},{"name":"School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob P. W.","family":"Rouhl","sequence":"additional","affiliation":[{"name":"Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands"},{"name":"Academic Center for Epileptology, Epilepsy Center Kempenhaeghe\/Maastricht, University Medical Center, Oosterhout, Heeze and Maastricht, The Netherlands"},{"name":"School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"S0129065718500120BIB001","first-page":"244","volume":"43","author":"Cooper I. S.","year":"1980","journal-title":"Appl. Neurophysiol."},{"key":"S0129065718500120BIB002","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.26001.x"},{"key":"S0129065718500120BIB003","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.01304.x"},{"key":"S0129065718500120BIB004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1987.tb05952.x"},{"key":"S0129065718500120BIB005","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000206364.19772.39"},{"key":"S0129065718500120BIB006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00898.x"},{"key":"S0129065718500120BIB007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02536.x"},{"key":"S0129065718500120BIB008","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001334"},{"key":"S0129065718500120BIB009","doi-asserted-by":"publisher","DOI":"10.1159\/000339991"},{"key":"S0129065718500120BIB010","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001197"},{"key":"S0129065718500120BIB011","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-015-2498-1"},{"key":"S0129065718500120BIB012","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2015.09.014"},{"key":"S0129065718500120BIB013","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-010-0835-y"},{"key":"S0129065718500120BIB014","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00730"},{"key":"S0129065718500120BIB015","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2015.06.003"},{"key":"S0129065718500120BIB016","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2015.00046"},{"key":"S0129065718500120BIB017","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn270"},{"key":"S0129065718500120BIB018","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.07.085"},{"key":"S0129065718500120BIB019","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.03.001"},{"key":"S0129065718500120BIB020","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002033420503"},{"key":"S0129065718500120BIB021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02397.x"},{"key":"S0129065718500120BIB022","doi-asserted-by":"publisher","DOI":"10.1159\/000366066"},{"key":"S0129065718500120BIB023","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2013.08.020"},{"key":"S0129065718500120BIB024","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.034"},{"key":"S0129065718500120BIB025","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-009-0494-4"},{"key":"S0129065718500120BIB026","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(00)00250-8"},{"key":"S0129065718500120BIB027","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(96)00081-7"},{"key":"S0129065718500120BIB028","doi-asserted-by":"publisher","DOI":"10.1016\/S0004-3702(97)00063-5"},{"key":"S0129065718500120BIB029","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-007-0856-9"},{"key":"S0129065718500120BIB030","doi-asserted-by":"publisher","DOI":"10.1159\/000444761"},{"key":"S0129065718500120BIB031","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13686"},{"key":"S0129065718500120BIB032","doi-asserted-by":"publisher","DOI":"10.3171\/2015.3.FOCUS1541"},{"key":"S0129065718500120BIB033","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.069"}],"container-title":["International Journal of Neural Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0129065718500120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T13:05:35Z","timestamp":1565183135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0129065718500120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":33,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2019,5,15]]},"published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1142\/S0129065718500120"],"URL":"https:\/\/doi.org\/10.1142\/s0129065718500120","relation":{},"ISSN":["0129-0657","1793-6462"],"issn-type":[{"value":"0129-0657","type":"print"},{"value":"1793-6462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]}}}