{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:07:16Z","timestamp":1760854036148},"reference-count":34,"publisher":"World Scientific Pub Co Pte Lt","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Neur. Syst."],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p> During neocortical seizures in patients with epilepsy, microelectrode array recordings from the ictal core show a strong correlation between the fast, cellular spiking activities and the low-frequency component of the potential field, reflected in the electrocorticogram (ECoG). Here, we model the relationship between the cellular spike activity and this low-frequency component as the input and output signals of a linear time invariant system. Our approach is based on the observation that this relationship can be characterized by a so-called sinc function, the unit impulse response of an ideal (brick-wall) filter. Accordingly, using a brick-wall filter, we are able to convert ictal cellular spike inputs into an output that significantly correlates with the observed seizure activity in the ECoG [Formula: see text], while ECoG recordings of subsequent seizures within patients also show significant, but lower, correlations [Formula: see text]. Furthermore, we can produce seizure-like output signals using synthetic spike trains with ictal properties. We propose a possible physiological mechanism to explain the observed properties associated with an ideal filter, and discuss the potential use of our approach for the evaluation of anticonvulsant strategies. <\/jats:p>","DOI":"10.1142\/s0129065718500272","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T23:12:34Z","timestamp":1529363554000},"page":"1850027","source":"Crossref","is-referenced-by-count":6,"title":["The Relationship Between Ictal Multi-Unit Activity and the Electrocorticogram"],"prefix":"10.1142","volume":"28","author":[{"given":"Tahra L.","family":"Eissa","sequence":"first","affiliation":[{"name":"Committee on Neurobiology, University of Chicago, 5801 S Ellis Ave, Chicago, IL 60637, USA"},{"name":"Department of Neurology, Columbia University, New York 10032, NY, USA"}]},{"given":"Catherine A.","family":"Schevon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University, 710 W 168th St, New York 10032, NY, USA"}]},{"given":"Ronald G.","family":"Emerson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University, 710 W 168th St, New York 10032, NY, USA"},{"name":"Department of Neurology, Weill Cornell Medical College, New York 10021, NY, USA"}]},{"suffix":"JR.","given":"Guy M.","family":"Mckhann","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Columbia University, 710 W 168th St, New York 10032, NY, USA"}]},{"given":"Robert R.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Columbia University, 710 W 168th St, New York 10032, NY, USA"},{"name":"Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA"}]},{"given":"Wim","family":"Van Drongelen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chicago, 900 E 57th St, Chicago, IL 60637, USA"}]}],"member":"219","published-online":{"date-parts":[[2018,12,16]]},"reference":[{"key":"S0129065718500272BIB001","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195301069.001.0001"},{"key":"S0129065718500272BIB002","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.239590"},{"key":"S0129065718500272BIB003","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11098"},{"key":"S0129065718500272BIB004","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2056"},{"key":"S0129065718500272BIB005","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1702490114"},{"key":"S0129065718500272BIB006","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14896"},{"key":"S0129065718500272BIB007","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2782"},{"key":"S0129065718500272BIB008","volume-title":"Signal Processing for Neuroscientists: Introduction to the Analysis of Physiological Signals","author":"van Drongelen W.","year":"2018","edition":"2"},{"key":"S0129065718500272BIB009","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(72)86068-5"},{"key":"S0129065718500272BIB010","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt276"},{"key":"S0129065718500272BIB011","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0141-15.2016"},{"key":"S0129065718500272BIB012","doi-asserted-by":"publisher","DOI":"10.1007\/BF00288786"},{"key":"S0129065718500272BIB013","doi-asserted-by":"publisher","DOI":"10.1186\/s13408-015-0019-4"},{"key":"S0129065718500272BIB014","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.06.015"},{"key":"S0129065718500272BIB015","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2787-06.2006"},{"key":"S0129065718500272BIB016","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0145-07.2007"},{"key":"S0129065718500272BIB017","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-16-07297.2002"},{"key":"S0129065718500272BIB018","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.040"},{"key":"S0129065718500272BIB019","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3357-10.2010"},{"key":"S0129065718500272BIB020","volume-title":"An Introduction to Epilepsy","author":"Bromfield E. 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