{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:33:19Z","timestamp":1772555599928,"version":"3.50.1"},"reference-count":89,"publisher":"World Scientific Pub Co Pte Lt","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Neur. Syst."],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p> Although electroconvulsive therapy (ECT) is one of the most effective treatments for major depressive disorder (MDD), the mechanism underlying the therapeutic efficacy and side effects of ECT remains poorly understood. Here, we investigated alterations in the cortical morphological measurements including cortical thickness (CT), surface area (SA), and local gyrification index (LGI) in 23 MDD patients before and after ECT. Furthermore, multivariate pattern analysis using linear support vector machine (SVM) was applied to investigate whether the changed morphological measurements can be effective indicators for therapeutic efficacy of ECT. Surface-based morphometry (SBM) analysis found significantly increased vertex-wise and regional cortical thickness (CT) and surface area (SA) in widespread regions, mainly located in the left insula (INS) and left fusiform gyrus, as well as hypergyrification in the left middle temporal gyrus (MTG) in MDD patients after ECT. Partial correlational analyses identified associations between the morphological properties and depressive symptom scores and impaired memory scores. Moreover, SVM result showed that the changed morphological measurements were effective to classify the MDD patients before and after ECT. Our findings suggested that ECT may enhance cortical neuroplasticity to facilitate neurogenesis to remit depressive symptoms and to impair delayed memory. These findings indicated that the cortical morphometry is a good index for therapeutic efficacy of ECT. <\/jats:p>","DOI":"10.1142\/s0129065719500059","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T08:03:46Z","timestamp":1549613026000},"page":"1950005","source":"Crossref","is-referenced-by-count":38,"title":["Electroconvulsive Therapy Induces Cortical Morphological Alterations in Major Depressive Disorder Revealed with Surface-Based Morphometry Analysis"],"prefix":"10.1142","volume":"29","author":[{"given":"Jinping","family":"Xu","sequence":"first","affiliation":[{"name":"Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, P. R. China"}]},{"given":"Jiaojian","family":"Wang","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 625014, P. R. China"}]},{"given":"Tongjian","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Hospital of Anhui Medical University, Hefei 230022, P. R. China"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China"}]},{"given":"Tian","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. 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China"}]},{"given":"Yanghua","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Hospital of Anhui Medical University, Hefei 230022, P. R. China"},{"name":"Department of Neurology, Shannan People\u2019s Hospital, Shannan, 856000, P. R. China"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Hospital of Anhui Medical University, Hefei 230022, P. R. China"},{"name":"Department of Medical Psychology, Anhui Medical University, Hefei 230022, P. R. China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, P. R. China"},{"name":"Collaborative Innovation Center for Neuropsychiatric Disorders and Mental Health, Hefei 230022, P. R. 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