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These analyses typically rely on a preprocessing step (pruning) to reduce computational complexity and remove the weakest edges that are most likely affected by experimental noise. However, weak links may contain relevant information about brain connectivity, therefore, the identification of the optimal trade-off between retained and discarded edges is a subject of active research. We introduce a pruning algorithm to identify edges that carry the highest information content. The algorithm selects both strong edges (i.e. edges belonging to shortest paths) and weak edges that are topologically relevant in weakly connected subnetworks. The newly developed \u201cstrong\u2013weak\u201d pruning (SWP) algorithm was validated on simulated networks that mimic the structure of human brain networks. It was then applied for the analysis of a real dataset of subjects affected by amyotrophic lateral sclerosis (ALS), both at the early (ALS2) and late (ALS3) stage of the disease, and of healthy control subjects. SWP preprocessing allowed identifying statistically significant differences in the path length of networks between patients and healthy subjects. ALS patients showed a decrease of connectivity between frontal cortex to temporal cortex and parietal cortex and between temporal and occipital cortex. Moreover, degree of centrality measures revealed significantly different hub and centrality scores between patient subgroups. These findings suggest a widespread alteration of network topology in ALS associated with disease progression.<\/jats:p>","DOI":"10.1142\/s0129065719500072","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T03:20:15Z","timestamp":1550200815000},"page":"1950007","source":"Crossref","is-referenced-by-count":8,"title":["Strong\u2013Weak Pruning for Brain Network Identification in Connectome-Wide Neuroimaging: Application to Amyotrophic Lateral Sclerosis Disease Stage Characterization"],"prefix":"10.1142","volume":"29","author":[{"given":"Angela","family":"Serra","sequence":"first","affiliation":[{"name":"NeuRoNeLab, Department of Management and Innovation Systems, University of Salerno, Fisciano (Sa), 84084, Italy"},{"name":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Galdi","sequence":"additional","affiliation":[{"name":"NeuRoNeLab, Department of Management and Innovation Systems, University of Salerno, Fisciano (Sa), 84084, Italy"},{"name":"MRC Centre for Reproductive Health, University of Edinburgh, EH16 4TJ Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Pesce","sequence":"additional","affiliation":[{"name":"NeuRoNeLab, Department of Management and Innovation Systems, University of Salerno, Fisciano (Sa), 84084, Italy"},{"name":"International Digital Laboratory, WMG, University of Coventry, CV4 7AL, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Fratello","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical, Neurological, Metabolic and Ageing Sciences, Universit\u00e0 Degli Studi Della Campania \u201cLuigi Vanvitelli\u201d, Napoli, 80138, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Trojsi","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical, Neurological, Metabolic and Ageing Sciences, Universit\u00e0 Degli Studi Della Campania \u201cLuigi Vanvitelli\u201d, Napoli, 80138, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gioacchino","family":"Tedeschi","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical, Neurological, Metabolic and Ageing Sciences, Universit\u00e0 Degli Studi Della Campania \u201cLuigi Vanvitelli\u201d, Napoli, 80138, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Tagliaferri","sequence":"additional","affiliation":[{"name":"NeuRoNeLab, Department of Management and Innovation Systems, University of Salerno, Fisciano (Sa), 84084, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d, University of Salerno, Baronissi (Sa), 84081, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2019,8,6]]},"reference":[{"key":"S0129065719500072BIB001","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0008"},{"key":"S0129065719500072BIB002","first-page":"19","volume":"4","author":"Fox M. 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