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We employed Scaled Subprofile Modeling using Principal Component Analysis as a preprocessing step to focus on specific brain regions and limit the number of voxels that are used as input for the CNNs, thereby increasing the signal-to-noise ratio in our data. We performed hyperparameter optimization on three CNN architectures to estimate the classification accuracy of the networks on new data. The best performance that we obtained was [Formula: see text] and area under the receiver operating characteristic curve [Formula: see text] on the test set. We believe that, with larger datasets, PD patients could be reliably distinguished from controls by FDG-PET scans alone and that this technique could be applied to more clinically challenging tasks, like the differential diagnosis of neurological disorders with similar symptoms, such as PD, Progressive Supranuclear Palsy (PSP) and Multiple System Atrophy (MSA).<\/jats:p>","DOI":"10.1142\/s0129065719500102","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T04:18:38Z","timestamp":1551673118000},"page":"1950010","source":"Crossref","is-referenced-by-count":59,"title":["Scaled Subprofile Modeling and Convolutional Neural Networks for the Identification of Parkinson\u2019s Disease in 3D Nuclear Imaging Data"],"prefix":"10.1142","volume":"29","author":[{"given":"Octavio Martinez","family":"Manzanera","sequence":"first","affiliation":[{"name":"Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands"}]},{"given":"Sanne K.","family":"Meles","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands"}]},{"given":"Klaus L.","family":"Leenders","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands"}]},{"given":"Remco J.","family":"Renken","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, University Medical Center Groningen, University of Groningen, A. Deusinglaan 1, Groningen, The Netherlands"}]},{"given":"Marco","family":"Pagani","sequence":"additional","affiliation":[{"name":"Institute of Cognitive Sciences and Technologies, Consiglio Nazionale delle Ricerche, via S. Martino della Battaglia, 44-00185 Rome, Italy"},{"name":"Department of Nuclear Medicine, Karolinska University Hospital, Huddinge, SE-141 86, Stockholm, Sweden"},{"name":"Department of Nuclear Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1,9713 GZ Groningen, The Netherlands"}]},{"given":"Dario","family":"Arnaldi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Opthalmology, Genetics and Maternal and Child Science (DINOGMI), University of Genoa Largo Paolo Daneo 3, 16132 Genoa, Italy"},{"name":"IRCCS AOU San Martino \u2014 IST, Largo R. 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