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Syst."],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>We investigated the functional network reorganization caused by low-frequency electrical stimulation (LFES) of human brain cortical surface. Intracranial EEG data from subdural grid positions were analyzed in 16 pre-surgery epileptic patients. LFES was performed by injecting current pulses (10[Formula: see text]mA, 0.2[Formula: see text]ms pulse width, 0.5[Formula: see text]Hz, 25 trials) into all adjacent electrode contacts. Dynamic functional connectivity analysis was carried out on two frequency bands (low: 1\u20134[Formula: see text]Hz; high: 10\u201340[Formula: see text]Hz) to investigate the early, high frequency and late, low frequency responses elicited by the stimulation. The centralization increased in early compared to late responses, suggesting a more prominent role of direct neural links between primarily activated areas and distant brain regions. Injecting the current into the seizure onset zone (SOZ) evoked a more integrated functional topology during the early (N1) period of the response, whereas during the late (N2) period \u2014 regardless of the stimulation site \u2014 the connectedness of the SOZ was elevated compared to the non-SOZ tissue. The abnormal behavior of the epileptic sub-network during both part of the responses supports the idea of the pathogenic role of impaired inhibition and excitation mechanisms in epilepsy.<\/jats:p>","DOI":"10.1142\/s0129065719500229","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T08:18:32Z","timestamp":1564388312000},"page":"1950022","source":"Crossref","is-referenced-by-count":5,"title":["Reorganization of Large-Scale Functional Networks During Low-Frequency Electrical Stimulation of the Cortical Surface"],"prefix":"10.1142","volume":"30","author":[{"given":"B\u00e1lint","family":"File","sequence":"first","affiliation":[{"name":"Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Budapest, H-1083, Hungary"},{"name":"Computational Neuroscience Group, Wigner Research Centre for Physics, HAS, Budapest, H-1121, 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