{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:24:10Z","timestamp":1778498650037,"version":"3.51.4"},"reference-count":59,"publisher":"World Scientific Pub Co Pte Lt","issue":"09","funder":[{"name":"MINECO\/FEDER","award":["RTI2018-098913-B-100"],"award-info":[{"award-number":["RTI2018-098913-B-100"]}]},{"name":"MINECO\/FEDER","award":["PGC2018-098813-B-C32"],"award-info":[{"award-number":["PGC2018-098813-B-C32"]}]},{"name":"Junta de Andalucia FEDER","award":["A-TIC-117-UGR18"],"award-info":[{"award-number":["A-TIC-117-UGR18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Neur. Syst."],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p> Finding new biomarkers to model Parkinson\u2019s Disease (PD) is a challenge not only to help discerning between Healthy Control (HC) subjects and patients with potential PD but also as a way to measure quantitatively the loss of dopaminergic neurons mainly concentrated at substantia nigra. Within this context, this work presented here tries to provide a set of imaging features based on morphological characteristics extracted from I[Formula: see text]-Ioflupane SPECT scans to discern between HC and PD participants in a balanced set of [Formula: see text] scans from Parkinson\u2019s Progression Markers Initiative (PPMI) database. These features, obtained from isosurfaces of each scan at different intensity levels, have been classified through the use of classical Machine Learning classifiers such as Support-Vector-Machines (SVM) or Na\u00efve Bayesian and compared with the results obtained using a Multi-Layer Perceptron (MLP). <\/jats:p><jats:p> The proposed system, based on a Mann\u2013Whitney\u2013Wilcoxon U-Test for feature selection and the SVM approach, yielded a [Formula: see text] balanced accuracy when the performance was evaluated using a [Formula: see text]-fold cross-validation. This proves the reliability of these biomarkers, especially those related to sphericity, center of mass, number of vertices, 2D-projected perimeter or the 2D-projected eccentricity, among others, but including both internal and external isosurfaces. <\/jats:p>","DOI":"10.1142\/s0129065720500446","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T03:05:07Z","timestamp":1589252707000},"page":"2050044","source":"Crossref","is-referenced-by-count":33,"title":["Morphological Characterization of Functional Brain Imaging by Isosurface Analysis in Parkinson\u2019s Disease"],"prefix":"10.1142","volume":"30","author":[{"given":"Diego","family":"Castillo-Barnes","sequence":"first","affiliation":[{"name":"Department of Signal Theory, Telematics and Communications, University of Granada, Periodista Daniel Saucedo Aranda, Granada 18071, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Martinez-Murcia","sequence":"additional","affiliation":[{"name":"Department of Communications Engineering, University of Malaga, Bulevar Louis Pasteur 35, Malaga 29071, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Communications Engineering, University of Malaga, Bulevar Louis Pasteur 35, Malaga 29071, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Salas-Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Signal Theory, Telematics and Communications, University of Granada, Periodista Daniel Saucedo Aranda, Granada 18071, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Ram\u00cdrez","sequence":"additional","affiliation":[{"name":"Department of Signal Theory, Telematics and Communications, University of Granada, Periodista Daniel Saucedo Aranda, Granada 18071, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan M.","family":"G\u00f3rriz","sequence":"additional","affiliation":[{"name":"Department of Signal Theory, Telematics and Communications, University of Granada, Periodista Daniel Saucedo Aranda, Granada 18071, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"S0129065720500446BIB001","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.217"},{"key":"S0129065720500446BIB002","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.131045"},{"key":"S0129065720500446BIB003","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2018.09.008"},{"key":"S0129065720500446BIB004","doi-asserted-by":"publisher","DOI":"10.1118\/1.4742055"},{"key":"S0129065720500446BIB005","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucom.2013.01.054"},{"key":"S0129065720500446BIB006","doi-asserted-by":"publisher","DOI":"10.1186\/s40658-016-0140-9"},{"key":"S0129065720500446BIB007","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.07.004"},{"key":"S0129065720500446BIB008","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09330-z"},{"key":"S0129065720500446BIB009","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6076-z"},{"key":"S0129065720500446BIB010","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2011.00583.x"},{"key":"S0129065720500446BIB011","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3971"},{"key":"S0129065720500446BIB012","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.11.2089"},{"key":"S0129065720500446BIB013","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00101"},{"key":"S0129065720500446BIB014","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2018.03.004"},{"key":"S0129065720500446BIB015","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00151"},{"key":"S0129065720500446BIB016","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065719500114"},{"key":"S0129065720500446BIB017","doi-asserted-by":"publisher","DOI":"10.1109\/NSSMIC.2018.8824575"},{"key":"S0129065720500446BIB018","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2016.2547901"},{"key":"S0129065720500446BIB019","doi-asserted-by":"publisher","DOI":"10.1109\/NSSMIC.2018.8824707"},{"key":"S0129065720500446BIB020","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-19591-5_37"},{"key":"S0129065720500446BIB021","doi-asserted-by":"publisher","DOI":"10.1016\/j.cag.2018.02.002"},{"key":"S0129065720500446BIB022","doi-asserted-by":"publisher","DOI":"10.1097\/WNN.0000000000000107"},{"key":"S0129065720500446BIB023","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27790"},{"key":"S0129065720500446BIB024","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-19591-5_39"},{"key":"S0129065720500446BIB025","doi-asserted-by":"publisher","DOI":"10.1080\/10867651.2003.10487582"},{"key":"S0129065720500446BIB026","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.453"},{"key":"S0129065720500446BIB027","doi-asserted-by":"publisher","DOI":"10.1145\/37401.37422"},{"key":"S0129065720500446BIB029","doi-asserted-by":"publisher","DOI":"10.1145\/235815.235821"},{"key":"S0129065720500446BIB030","volume-title":"Statistical Learning Theory","author":"Vapnik V.","year":"1998","edition":"1"},{"key":"S0129065720500446BIB031","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0026683"},{"key":"S0129065720500446BIB032","first-page":"281","volume":"13","author":"Bergstra J.","year":"2012","journal-title":"J. Mach. Learn. Res."},{"key":"S0129065720500446BIB033","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-76153-9_5"},{"key":"S0129065720500446BIB034","doi-asserted-by":"publisher","DOI":"10.1002\/asmb.537"},{"key":"S0129065720500446BIB035","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-51461-6_3"},{"key":"S0129065720500446BIB038","first-page":"1929","volume":"15","author":"Srivastava N.","year":"2014","journal-title":"J. Mach. Learn. Res."},{"key":"S0129065720500446BIB039","first-page":"1137","volume-title":"IJCAI\u201995 proc. 14th Int. Joint Conf. Artificial Intelligence, IJCAI\u201995","volume":"2","author":"Kohavi R.","year":"1995"},{"key":"S0129065720500446BIB040","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-6-10"},{"key":"S0129065720500446BIB041","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-84858-7"},{"key":"S0129065720500446BIB042","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-015-9262-9"},{"key":"S0129065720500446BIB043","first-page":"2825","volume":"12","author":"Pedregosa F.","year":"2011","journal-title":"J. Mach. Learn. Res."},{"key":"S0129065720500446BIB044","first-page":"1889","volume":"6","author":"Fan R.-E.","year":"2005","journal-title":"J. Mach. Learn. Res."},{"key":"S0129065720500446BIB045","first-page":"8024","author":"Paszke A.","year":"2019","journal-title":"Adv. Neural Inf. Process. Syst."},{"key":"S0129065720500446BIB046","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177730491"},{"key":"S0129065720500446BIB047","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2018.00053"},{"key":"S0129065720500446BIB048","first-page":"100","volume-title":"Advances in Intelligent Systems and Computing","volume":"771","author":"Castillo-Barnes D.","year":"2018"},{"key":"S0129065720500446BIB049","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.08.061"},{"key":"S0129065720500446BIB050","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00092"},{"key":"S0129065720500446BIB051","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00145"},{"key":"S0129065720500446BIB052","doi-asserted-by":"publisher","DOI":"10.3233\/ICA-180580"},{"key":"S0129065720500446BIB053","doi-asserted-by":"publisher","DOI":"10.3233\/ICA-180584"},{"key":"S0129065720500446BIB054","doi-asserted-by":"publisher","DOI":"10.3233\/ICA-180596"},{"key":"S0129065720500446BIB055","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2017.09.017"},{"key":"S0129065720500446BIB056","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065718500090"},{"key":"S0129065720500446BIB057","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065718500351"},{"key":"S0129065720500446BIB058","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065719500102"},{"key":"S0129065720500446BIB059","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065718500156"},{"key":"S0129065720500446BIB060","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065718500119"},{"key":"S0129065720500446BIB061","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065718500375"},{"key":"S0129065720500446BIB062","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065718500211"}],"container-title":["International Journal of Neural Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0129065720500446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T12:39:06Z","timestamp":1599655146000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0129065720500446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,12]]},"references-count":59,"journal-issue":{"issue":"09","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1142\/S0129065720500446"],"URL":"https:\/\/doi.org\/10.1142\/s0129065720500446","relation":{},"ISSN":["0129-0657","1793-6462"],"issn-type":[{"value":"0129-0657","type":"print"},{"value":"1793-6462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,12]]}}}