{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:46:41Z","timestamp":1777571201920,"version":"3.51.4"},"reference-count":74,"publisher":"World Scientific Pub Co Pte Lt","issue":"12","funder":[{"name":"Engineering and Physical Science Research Council (EPSRC), APB","award":["EP\/F023057\/1"],"award-info":[{"award-number":["EP\/F023057\/1"]}]},{"name":"EPSRC Fellowship","award":["EP\/I022325\/1"],"award-info":[{"award-number":["EP\/I022325\/1"]}]},{"name":"The Research Foundation Flanders","award":["1211820N"],"award-info":[{"award-number":["1211820N"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Neur. Syst."],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p> Intrinsic brain activity is organized into large-scale networks displaying specific structural\u2013functional architecture, known as resting-state networks (RSNs). RSNs reflect complex neurophysiological processes and interactions, and have a central role in distinct sensory and cognitive functions, making it crucial to understand and quantify their anatomical and functional properties. Fractal dimension (FD) provides a parsimonious way of summarizing self-similarity over different spatial and temporal scales but despite its suitability for functional magnetic resonance imaging (fMRI) signal analysis its ability to characterize and investigate RSNs is poorly understood. We used FD in a large sample of healthy participants to differentiate fMRI RSNs and examine how the FD property of RSNs is linked with their functional roles. We identified two clusters of RSNs, one mainly consisting of sensory networks (C1, including auditory, sensorimotor and visual networks) and the other more related to higher cognitive (HCN) functions (C2, including dorsal default mode network and fronto-parietal networks). These clusters were defined in a completely data-driven manner using hierarchical clustering, suggesting that quantification of Blood Oxygen Level Dependent (BOLD) signal complexity with FD is able to characterize meaningful physiological and functional variability. Understanding the mechanisms underlying functional RSNs, and developing tools to study their signal properties, is essential for assessing specific brain alterations and FD could potentially be used for the early detection and treatment of neurological disorders. <\/jats:p>","DOI":"10.1142\/s0129065720500616","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T08:22:57Z","timestamp":1596442977000},"page":"2050061","source":"Crossref","is-referenced-by-count":35,"title":["Characterisation of Haemodynamic Activity in Resting State Networks by Fractal Analysis"],"prefix":"10.1142","volume":"30","author":[{"given":"Camillo","family":"Porcaro","sequence":"first","affiliation":[{"name":"Institute of Cognitive Sciences and Technologies (ISTC) \u2014 National Research Council (CNR) Rome, Italy"},{"name":"Centre for Human Brain Health and School of Psychology, University of Birmingham, Birmingham, UK"},{"name":"S. Anna Institute and Research in Advanced Neurorehabilitation (RAN), Crotone, Italy"},{"name":"Department of Information Engineering \u2014 Universit\u00e0, Politecnica delle Marche, Ancona, Italy"},{"name":"Research Center for Motor Control and Neuroplasticity, KU Leuven, Leuven, Belgium"}]},{"given":"Stephen D.","family":"Mayhew","sequence":"additional","affiliation":[{"name":"Centre for Human Brain Health and School of Psychology, University of Birmingham, Birmingham, UK"}]},{"given":"Marco","family":"Marino","sequence":"additional","affiliation":[{"name":"Research Center for Motor Control and Neuroplasticity, KU Leuven, Leuven, Belgium"},{"name":"Brain Imaging and Neural Dynamics Research Group, IRCCS San Camillo Hospital, Venice, Italy"}]},{"given":"Dante","family":"Mantini","sequence":"additional","affiliation":[{"name":"Research Center for Motor Control and Neuroplasticity, KU Leuven, Leuven, Belgium"},{"name":"Brain Imaging and Neural Dynamics Research Group, IRCCS San Camillo Hospital, Venice, Italy"}]},{"given":"Andrew P.","family":"Bagshaw","sequence":"additional","affiliation":[{"name":"Centre for Human Brain Health and School of Psychology, University of Birmingham, Birmingham, UK"}]}],"member":"219","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"issue":"4","key":"S0129065720500616BIB001","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/mrm.1910340409","volume":"34","author":"Biswal B.","year":"1995","journal-title":"Magnetic Resonance in Medicine"},{"key":"S0129065720500616BIB002","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1146\/annurev.neuro.29.051605.112819","volume":"29","author":"Raichle M. 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