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J. Neur. Syst."],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p> The dynamic profile of brain function has received much attention in recent years and is also a focus in the study of epilepsy. The present study aims to integrate the dynamics of temporal and spatial characteristics to provide comprehensive and novel understanding of epileptic dynamics. Resting state fMRI data were collected from eighty-three patients with idiopathic generalized epilepsy (IGE) and 87 healthy controls (HC). Specifically, we explored the temporal and spatial variation of functional connectivity density (tvFCD and svFCD) in the whole brain. Using a sliding-window approach, for a given region, the standard variation of the FCD series was calculated as the tvFCD and the variation of voxel-wise spatial distribution was calculated as the svFCD. We found primary, high-level, and sub-cortical networks demonstrated distinct tvFCD and svFCD patterns in HC. In general, the high-level networks showed the highest variation, the subcortical and primary networks showed moderate variation, and the limbic system showed the lowest variation. Relative to HC, the patients with IGE showed weaken temporal and enhanced spatial variation in the default mode network and weaken temporospatial variation in the subcortical network. Besides, enhanced temporospatial variation in sensorimotor and high-level networks was also observed in patients. The hyper-synchronization of specific brain networks was inferred to be associated with the phenomenon responsible for the intrinsic propensity of generation and propagation of epileptic activities. The disrupted dynamic characteristics of sensorimotor and high-level networks might potentially contribute to the driven motion and cognition phenotypes in patients. In all, presently provided evidence from the temporospatial variation of functional interaction shed light on the dynamics underlying neuropathological profiles of epilepsy. <\/jats:p>","DOI":"10.1142\/s0129065720500653","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T15:32:59Z","timestamp":1598887979000},"page":"2050065","source":"Crossref","is-referenced-by-count":19,"title":["Dynamic Temporospatial Patterns of Functional Connectivity and Alterations in Idiopathic Generalized Epilepsy"],"prefix":"10.1142","volume":"30","author":[{"given":"Sisi","family":"Jiang","sequence":"first","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, P. R. China"}]},{"given":"Haonan","family":"Pei","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, P. R. China"}]},{"given":"Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, P. R. 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China"}]},{"given":"Jianfu","family":"Li","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, P. R. China"}]},{"given":"Hui","family":"He","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, P. R. 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