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These epileptiform discharges are initially sensitive to the application of [Formula: see text]-methyl-D-aspartate (NMDA) receptor antagonists, but these antagonists may lose their effectiveness with prolonged exposure to low [Mg[Formula: see text]], when extracellular Ca[Formula: see text] reduction occurs, typical of ictal periods, indicating the absence of synaptic connections. The study herein presented aimed at investigating the effect of reducing the [Mg[Formula: see text]] during the induction of Nonsynaptic Epileptiform Activities (NSEA). As an experimental protocol, NSEA were induced in rat hippocampal dentate gyrus (DG), using a bath solution containing high-K[Formula: see text] and zero-added-Ca[Formula: see text]. Additionally, computer simulations were performed using a mathematical model that represents electrochemical characteristics of the tissue of the DG granular layer. The experimental results show that the reduction of [Mg[Formula: see text]] causes an increase in the duration of the ictal period and a reduction in the interictal period, intensifying epileptiform discharges. The computer simulations suggest that the reduction of the Mg[Formula: see text] level intensifies the epileptiform discharges by a joint effect of reducing the surface charge screening and reducing the activity of the Na\/K pump. <\/jats:p>","DOI":"10.1142\/s0129065720500707","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T15:58:33Z","timestamp":1601567913000},"page":"2050070","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Low Magnesium Concentration on Ictal Discharges In A Non-Synaptic Model"],"prefix":"10.1142","volume":"31","author":[{"given":"Ant\u00f4nio M\u00e1rcio","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancia, Experimental e Computacional, Departamento de Engenharia de, Biossistemas Universidade Federal de S\u00e3o Jo\u00e3o del-Rei, Pr. 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