{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T23:22:32Z","timestamp":1773184952506,"version":"3.50.1"},"reference-count":62,"publisher":"World Scientific Pub Co Pte Lt","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Neur. Syst."],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p> Very fast ripples (VFRs, 500\u20131000[Formula: see text]Hz) are considered more specific than high-frequency oscillations (80\u2013500[Formula: see text]Hz) as biomarkers of epileptogenic zones. Although VFRs are frequent abnormal phenomena in epileptic seizures, their functional roles remain unclear. Here, we detected the VFRs in the hippocampal network and tracked their roles during status epilepticus (SE) in rats with pilocarpine-induced temporal lobe epilepsy (TLE). All regions in the hippocampal network exhibited VFRs in the baseline, preictal, ictal and postictal states, with the ictal state containing the most VFRs. Moreover, strong phase-locking couplings existed between VFRs and slow oscillations (1\u201312[Formula: see text]Hz) in the ictal and postictal states for all regions. Further investigation indicated that during VFRs, the build-up of slow oscillations in the ictal state began from the temporal lobe and then spread through the whole hippocampal network via two different pathways, which might be associated with the underlying propagation of epileptiform discharges in the hippocampal network. Overall, we provide a functional description of the emergence of VFRs in the hippocampal network during SE, and we also establish that VFRs may be the physiological representation of the pathological alterations in hippocampal network activity during SE in TLE. <\/jats:p>","DOI":"10.1142\/s0129065721500027","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T10:09:17Z","timestamp":1604484557000},"page":"2150002","source":"Crossref","is-referenced-by-count":12,"title":["Roles of Very Fast Ripple (500\u20131000Hz) in the Hippocampal Network During Status Epilepticus"],"prefix":"10.1142","volume":"31","author":[{"given":"Jianmin","family":"Hao","sequence":"first","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic, Science and Technology of China, Chengdu Sichuan 611731, P. R. China"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic, Science and Technology of China, Chengdu Sichuan 611731, P. R. China"}]},{"given":"Bochao","family":"Niu","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic, Science and Technology of China, Chengdu Sichuan 611731, P. R. China"}]},{"given":"Liang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sichuan Academy of Medical, Sciences and Sichuan Provincial People\u2019s Hospital, Chengdu Sichuan, P. R. China"}]},{"given":"Yuhang","family":"Lin","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic, Science and Technology of China, Chengdu Sichuan 611731, P. R. China"}]},{"given":"Yang","family":"Xia","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic, Science and Technology of China, Chengdu Sichuan 611731, P. R. China"}]},{"given":"Dezhong","family":"Yao","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic, Science and Technology of China, Chengdu Sichuan 611731, P. R. China"},{"name":"School of Electrical Engineering, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China"}]},{"given":"Daqing","family":"Guo","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic, Science and Technology of China, Chengdu Sichuan 611731, P. R. 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