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At present, most seizure detection methods are highly patient-dependent and have poor generalization performance. In this study, a novel patient-independent approach is proposed to effectively detect seizure onsets. First, the multi-channel EEG recordings are preprocessed by wavelet decomposition. Then, the Convolutional Neural Network (CNN) with proper depth works as an EEG feature extractor. Next, the obtained features are fed into a Bidirectional Long Short-Term Memory (BiLSTM) network to further capture the temporal variation characteristics. Finally, aiming to reduce the false detection rate (FDR) and improve the sensitivity, the postprocessing, including smoothing and collar, is performed on the outputs of the model. During the training stage, a novel channel perturbation technique is introduced to enhance the model generalization ability. The proposed approach is comprehensively evaluated on the CHB-MIT public scalp EEG database as well as a more challenging SH-SDU scalp EEG database we collected. Segment-based average accuracies of 97.51% and 93.70%, event-based average sensitivities of 86.51% and 89.89%, and average AUC-ROC of 90.82% and 90.75% are yielded on the CHB-MIT database and SH-SDU database, respectively. <\/jats:p>","DOI":"10.1142\/s0129065721500519","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T09:51:56Z","timestamp":1637056316000},"source":"Crossref","is-referenced-by-count":74,"title":["Patient-Independent Seizure Detection Based on Channel-Perturbation Convolutional Neural Network and Bidirectional Long Short-Term Memory"],"prefix":"10.1142","volume":"32","author":[{"given":"Guoyang","family":"Liu","sequence":"first","affiliation":[{"name":"School of Microelectronics, Shandong University, Jinan 250100, P. R. 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