{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T11:06:50Z","timestamp":1772881610608,"version":"3.50.1"},"reference-count":76,"publisher":"World Scientific Pub Co Pte Ltd","issue":"02","funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["62001205"],"award-info":[{"award-number":["62001205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong Natural Science Foundation Joint Fund","award":["2019A1515111038"],"award-info":[{"award-number":["2019A1515111038"]}]},{"name":"Shenzhen Science and Technology Innovation Committee","award":["20200925155957004"],"award-info":[{"award-number":["20200925155957004"]}]},{"name":"Shenzhen Science and Technology Innovation Committee","award":["KCXFZ2020122117340001"],"award-info":[{"award-number":["KCXFZ2020122117340001"]}]},{"name":"Shenzhen Science and Technology Innovation Committee","award":["SGDX2020110309280100"],"award-info":[{"award-number":["SGDX2020110309280100"]}]},{"name":"Shenzhen Key Laboratory of Smart Healthcare Engineering","award":["ZDSYS20200811144003009"],"award-info":[{"award-number":["ZDSYS20200811144003009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Neur. Syst."],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p> The oxytocin effects on large-scale brain networks such as Default Mode Network (DMN) and Frontoparietal Network (FPN) have been largely studied using fMRI data. However, these studies are mainly based on the statistical correlation or Bayesian causality inference, lacking interpretability at the physical and neuroscience level. Here, we propose a physics-based framework of the Kuramoto model to investigate oxytocin effects on the phase dynamic neural coupling in DMN and FPN. Testing on fMRI data of 59 participants administrated with either oxytocin or placebo, we demonstrate that oxytocin changes the topology of brain communities in DMN and FPN, leading to higher synchronization in the FPN and lower synchronization in the DMN, as well as a higher variance of the coupling strength within the DMN and more flexible coupling patterns at group level. These results together indicate that oxytocin may increase the ability to overcome the corresponding internal oscillation dispersion and support the flexibility in neural synchrony in various social contexts, providing new evidence for explaining the oxytocin modulated social behaviors. Our proposed Kuramoto model-based framework can be a potential tool in network neuroscience and offers physical and neural insights into phase dynamics of the brain. <\/jats:p>","DOI":"10.1142\/s0129065722500022","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T06:18:59Z","timestamp":1633933139000},"source":"Crossref","is-referenced-by-count":16,"title":["Kuramoto Model-Based Analysis Reveals Oxytocin Effects on Brain Network Dynamics"],"prefix":"10.1142","volume":"32","author":[{"given":"Shuhan","family":"Zheng","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, P. R. China"}]},{"given":"Zhichao","family":"Liang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, P. R. China"}]},{"given":"Youzhi","family":"Qu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, P. R. China"}]},{"given":"Qingyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive, Neuroscience and Learning & IDG\/McGovern, Institute for Brain Research, Beijing, Normal University, 100875 Beijing, P. R. China"}]},{"given":"Haiyan","family":"Wu","sequence":"additional","affiliation":[{"name":"Centre for Cognitive and Brain Sciences and Department of Psychology, University of Macau, Macau, P. R. China"}]},{"given":"Quanying","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Smart Healthcare Engineering, Southern University of Science and Technology, Shenzhen 518005, P. R. China"}]}],"member":"219","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"S0129065722500022BIB001","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.04.009"},{"key":"S0129065722500022BIB002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2012.08.020"},{"key":"S0129065722500022BIB003","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0038-8"},{"issue":"4","key":"S0129065722500022BIB004","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0896-6273(04)00043-1","volume":"41","author":"Bennett M. V.","year":"2004","journal-title":"Neuron"},{"key":"S0129065722500022BIB005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13408-020-00086-9","volume":"10","author":"Bick C.","year":"2020","journal-title":"J. Math. Neurosci."},{"issue":"2","key":"S0129065722500022BIB006","first-page":"2090","volume":"1","author":"Biswas B.","year":"2013","journal-title":"Electron. J. Math. Anal. Appl."},{"key":"S0129065722500022BIB007","doi-asserted-by":"publisher","DOI":"10.1088\/1742-5468\/2008\/10\/P10008"},{"key":"S0129065722500022BIB008","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2010.00190"},{"issue":"7","key":"S0129065722500022BIB009","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1089\/brain.2017.0528","volume":"7","author":"Brodmann K.","year":"2017","journal-title":"Brain Connect."},{"key":"S0129065722500022BIB010","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065707000968"},{"issue":"3","key":"S0129065722500022BIB011","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.yhbeh.2011.12.003","volume":"61","author":"Churchland P. S.","year":"2012","journal-title":"Horm. Behav."},{"issue":"28","key":"S0129065722500022BIB012","doi-asserted-by":"crossref","first-page":"11583","DOI":"10.1073\/pnas.1220826110","volume":"110","author":"Crossley N. A.","year":"2013","journal-title":"Proc. Nat. Acad. Sci."},{"issue":"3","key":"S0129065722500022BIB013","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.biopsych.2015.03.020","volume":"79","author":"De Dreu C. K.","year":"2016","journal-title":"Biol. Psych."},{"issue":"1","key":"S0129065722500022BIB014","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrn2961","volume":"12","author":"Deco G.","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"S0129065722500022BIB015","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.10.009"},{"issue":"7","key":"S0129065722500022BIB016","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1162\/NECO_a_00978","volume":"29","author":"Dodla R.","year":"2017","journal-title":"Neural Comput."},{"issue":"1","key":"S0129065722500022BIB017","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1214\/16-BA1030","volume":"13","author":"Durante D.","year":"2018","journal-title":"Bayesian Anal."},{"key":"S0129065722500022BIB018","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-87708-2","volume-title":"Mathematical Foundations of Neuroscience","volume":"35","author":"Ermentrout G. B.","year":"2010"},{"key":"S0129065722500022BIB019","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065720500513"},{"key":"S0129065722500022BIB020","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"S0129065722500022BIB021","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065720500021"},{"issue":"5","key":"S0129065722500022BIB022","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1109\/JPROC.2017.2786710","volume":"106","author":"Garcia J. O.","year":"2018","journal-title":"Proc. IEEE"},{"issue":"1","key":"S0129065722500022BIB023","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/brain.2013.0210","volume":"5","author":"Gohel S. R.","year":"2015","journal-title":"Brain Connect."},{"issue":"2","key":"S0129065722500022BIB024","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1523\/JNEUROSCI.1853-13.2014","volume":"34","author":"Hellyer P. J.","year":"2014","journal-title":"J. Neurosci."},{"key":"S0129065722500022BIB025","doi-asserted-by":"crossref","first-page":"117668","DOI":"10.1016\/j.neuroimage.2020.117668","volume":"227","author":"Jiang X.","year":"2020","journal-title":"NeuroImage"},{"issue":"2","key":"S0129065722500022BIB026","doi-asserted-by":"crossref","first-page":"193","DOI":"10.31887\/DCNS.2017.19.2\/cjones","volume":"19","author":"Jones C.","year":"2017","journal-title":"Dialogues Clin. Neurosci."},{"key":"S0129065722500022BIB027","doi-asserted-by":"crossref","first-page":"e61844","DOI":"10.7554\/eLife.61844","volume":"10","author":"Kapetaniou G. E.","year":"2021","journal-title":"Elife"},{"issue":"2","key":"S0129065722500022BIB028","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1162\/netn_a_00070","volume":"3","author":"Kashyap A.","year":"2019","journal-title":"Netw. Neurosci."},{"key":"S0129065722500022BIB029","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000314"},{"issue":"8","key":"S0129065722500022BIB030","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1038\/npp.2016.1","volume":"41","author":"Koch S.","year":"2106","journal-title":"Neuropsychopharmacology"},{"issue":"17","key":"S0129065722500022BIB031","doi-asserted-by":"crossref","first-page":"9566","DOI":"10.1073\/pnas.1921475117","volume":"117","author":"Kringelbach M. L.","year":"2020","journal-title":"Proc. Nat. Acad. Sci."},{"issue":"9","key":"S0129065722500022BIB032","first-page":"567","volume":"270","author":"Kumar J.","year":"2019","journal-title":"Eur. Archiv. Psych. Clin. Neurosci."},{"key":"S0129065722500022BIB033","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1143\/PTPS.79.223","volume":"79","author":"Kuramoto Y.","year":"1984","journal-title":"Progress Theor. Phys. Suppl."},{"key":"S0129065722500022BIB034","volume-title":"Chemical Oscillations, Waves, and Turbulence","author":"Kuramoto Y.","year":"2003"},{"key":"S0129065722500022BIB035","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23688"},{"key":"S0129065722500022BIB036","doi-asserted-by":"crossref","first-page":"106666","DOI":"10.1016\/j.knosys.2020.106666","volume":"213","author":"Ma C.","year":"2020","journal-title":"Knowl. Based Syst."},{"issue":"5","key":"S0129065722500022BIB037","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1109\/TKDE.2017.2657752","volume":"29","author":"Ma X.","year":"2017","journal-title":"IEEE Trans. Knowl. Data Eng."},{"issue":"2","key":"S0129065722500022BIB038","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tics.2015.10.009","volume":"20","author":"Ma Y.","year":"2016","journal-title":"Trends Cogn. Sci."},{"key":"S0129065722500022BIB039","doi-asserted-by":"publisher","DOI":"10.1177\/155005941004100103"},{"issue":"2","key":"S0129065722500022BIB040","doi-asserted-by":"crossref","first-page":"133","DOI":"10.31887\/DCNS.2018.20.2\/smarek","volume":"20","author":"Marek S.","year":"2018","journal-title":"Dialog. Clin. Neurosci."},{"key":"S0129065722500022BIB041","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24458"},{"issue":"2","key":"S0129065722500022BIB042","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2015.09.029","volume":"163","author":"Markram H.","year":"2015","journal-title":"Cell"},{"key":"S0129065722500022BIB043","author":"Marsh N.","year":"2020","journal-title":"Neuroscientist"},{"issue":"1","key":"S0129065722500022BIB044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-13993-7","volume":"11","author":"Martinet L.-E.","year":"2020","journal-title":"Nat. Commun."},{"issue":"4","key":"S0129065722500022BIB045","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/scan\/nsw169","volume":"12","author":"Morawetz C.","year":"2017","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"S0129065722500022BIB046","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.yhbeh.2016.01.015","volume":"80","author":"Ne\u2019eman R.","year":"2016","journal-title":"Horm. Behav."},{"issue":"1","key":"S0129065722500022BIB047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-54769-9","volume":"9","author":"\u00d3dor G.","year":"2019","journal-title":"Sci. Rep."},{"key":"S0129065722500022BIB048","doi-asserted-by":"crossref","first-page":"113337","DOI":"10.1016\/j.ygcen.2019.113337","volume":"286","author":"Olaz\u00e1bal D. E.","year":"2020","journal-title":"Gen. Comp. Endocrinol."},{"issue":"5","key":"S0129065722500022BIB049","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.yhbeh.2005.12.010","volume":"49","author":"Olazabal D. E.","year":"2006","journal-title":"Horm. Behav."},{"key":"S0129065722500022BIB050","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.10.003"},{"issue":"9","key":"S0129065722500022BIB051","doi-asserted-by":"crossref","first-page":"2050046","DOI":"10.1142\/S012906572050046X","volume":"30","author":"Ozel P.","year":"2020","journal-title":"Int. J. Neural Syst."},{"key":"S0129065722500022BIB052","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.yhbeh.2017.03.006","volume":"90","author":"Pfundmair M.","year":"2017","journal-title":"Horm. Behav."},{"key":"S0129065722500022BIB053","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.12.061"},{"issue":"7","key":"S0129065722500022BIB054","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tics.2020.03.008","volume":"24","author":"Quintana D. S.","year":"2020","journal-title":"Trends Cognit. Sci."},{"key":"S0129065722500022BIB055","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071013-014030"},{"issue":"4","key":"S0129065722500022BIB056","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.neuroscience.2009.05.055","volume":"162","author":"Ross H. E.","year":"2009","journal-title":"Neuroscience"},{"key":"S0129065722500022BIB057","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.003"},{"key":"S0129065722500022BIB058","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neuroimage.2019.07.007","volume":"200","author":"Samogin J.","year":"2019","journal-title":"NeuroImage"},{"key":"S0129065722500022BIB059","doi-asserted-by":"crossref","first-page":"117431","DOI":"10.1016\/j.neuroimage.2020.117431","volume":"225","author":"Sanchez-Rodriguez L. M.","year":"2021","journal-title":"NeuroImage"},{"issue":"1","key":"S0129065722500022BIB060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-49636-6","volume":"9","author":"Schiller B.","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"S0129065722500022BIB061","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12868-015-0140-z","volume":"16","author":"Schmidt R.","year":"2015","journal-title":"BMC Neurosci."},{"key":"S0129065722500022BIB062","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05888.x"},{"issue":"1","key":"S0129065722500022BIB063","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s41109-016-0007-y","volume":"1","author":"Taya F.","year":"2016","journal-title":"Appl. Netw. Sci."},{"issue":"1","key":"S0129065722500022BIB064","first-page":"1","volume":"4","author":"Villegas P.","year":"2014","journal-title":"Sci. Rep."},{"key":"S0129065722500022BIB065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2014.04.039","volume":"97","author":"Vuksanovi\u0107 V.","year":"2014","journal-title":"NeuroImage"},{"key":"S0129065722500022BIB066","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065718500557"},{"key":"S0129065722500022BIB067","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuroscience.2019.11.006","volume":"425","author":"Wang X.","year":"2020","journal-title":"Neuroscience"},{"issue":"6","key":"S0129065722500022BIB068","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1007\/s11682-019-00205-5","volume":"14","author":"Wu H.","year":"2020","journal-title":"Brain Imag. Behav."},{"issue":"3","key":"S0129065722500022BIB069","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1093\/cercor\/bhy295","volume":"31","author":"Xin F.","year":"2021","journal-title":"Cerebral Cortex"},{"key":"S0129065722500022BIB070","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.3389\/fpsyg.2017.01538","volume":"8","author":"Xu Y.","year":"2017","journal-title":"Front. Psychol."},{"key":"S0129065722500022BIB071","doi-asserted-by":"crossref","first-page":"104597","DOI":"10.1016\/j.psyneuen.2020.104597","volume":"114","author":"Yang S.","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"S0129065722500022BIB072","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41583-020-00420-w","volume":"22","author":"Yeshurun Y.","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"S0129065722500022BIB073","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neuroscience.2021.01.018","volume":"459","author":"Zheng S.","year":"2021","journal-title":"Neuroscience"},{"key":"S0129065722500022BIB074","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.psyneuen.2019.06.016","volume":"108","author":"Zhu R.","year":"2019","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"S0129065722500022BIB075","doi-asserted-by":"crossref","first-page":"2150001","DOI":"10.1142\/S0129065721500015","volume":"31","author":"Zhu Y.","year":"2021","journal-title":"Int. J. Neural Syst."},{"issue":"1","key":"S0129065722500022BIB076","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/0269881120972347","volume":"35","author":"Zhuang Q.","year":"2021","journal-title":"J. Psychopharmacol."}],"container-title":["International Journal of Neural Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0129065722500022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T11:35:14Z","timestamp":1642764914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0129065722500022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,2]]},"references-count":76,"journal-issue":{"issue":"02","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1142\/S0129065722500022"],"URL":"https:\/\/doi.org\/10.1142\/s0129065722500022","relation":{},"ISSN":["0129-0657","1793-6462"],"issn-type":[{"value":"0129-0657","type":"print"},{"value":"1793-6462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,2]]},"article-number":"2250002"}}